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. 2018 Mar;479(1):62-65.
doi: 10.1134/S1607672918020023. Epub 2018 May 19.

MNT Optimization for Intracellular Delivery of Antibody Fragments

A V Ulasov  1 , Y V Khramtsov  1 , T N Lupanova  1 , A D Tsvetkova  1   2 , A A Rosenkranz  1   2 , T A Slastnikova  1 , G P Georgiev  1 , A S Sobolev  3   4
Affiliations

MNT Optimization for Intracellular Delivery of Antibody Fragments

A V Ulasov et al. Dokl Biochem Biophys. 2018 Mar.

Abstract

We studied the possibility of optimizing modular nanotransporters (MNTs) for the intracellular delivery of antibody fragments into the nuclei of cells of a specified type. Basic MNT with a reduced size retaining the desired functions was obtained, and the principal possibility of obtaining an MNT carrying an antibody fragment by microbiological synthesis was shown.

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