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. 2018 Mar;479(1):108-110.
doi: 10.1134/S160767291802014X. Epub 2018 May 19.

Translocation of Oligonucleotide-Oligosaccharide Complexes into Cells of the Brain

N N Dygalo  1   2 , T S Kalinina  3   4 , D A Lanshakov  3
Affiliations

Translocation of Oligonucleotide-Oligosaccharide Complexes into Cells of the Brain

N N Dygalo et al. Dokl Biochem Biophys. 2018 Mar.

Abstract

Irradiation of a mixture of oligonucleotides with dextran resulted in the formation of a complex that is detected by a decelerated migration of an irradiated sample in electrophoretic gel compared to a non-irradiated one. When injected into the brain of neonatal rats, the formed complex penetrated into the cells 3 times easier compared to the original oligonucleotide, thus indicating that the use of radiation crosslinking of oligonucleotides with oligosaccharides is promising to enhance the efficiency of delivery of gene-targeted oligonucleotide drugs into cells.

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