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Case Reports
. 2018 Oct 15;57(20):3047-3050.
doi: 10.2169/internalmedicine.1005-18. Epub 2018 May 18.

Cytomegalovirus Hemorrhagic Cystitis in a Malignant Glioma Patient Treated with Temozolomide

Ryutaro Furukawa  1 , Hirokuni Homma  2 , Tomohiro Inoue  2 , Hajime Horiuchi  3 , Kazuhiro Usui  1
Affiliations
Case Reports

Cytomegalovirus Hemorrhagic Cystitis in a Malignant Glioma Patient Treated with Temozolomide

Ryutaro Furukawa et al. Intern Med. .

Abstract

Temozolomide, a key drug in the treatment of malignant glioma, can cause profound lymphopenia and various opportunistic infectious diseases. A 79-year-old woman with anaplastic oligodendroglioma developed a fever and gross hematuria after 8 weeks of standard radiotherapy with concomitant temozolomide treatment. A cytomegalovirus (CMV) antigen test for pp65 antigenemia was positive (137 cells per 75,800 leukocytes), and the findings from a urine cytology test were consistent with CMV-induced hemorrhagic cystitis. She was treated with ganciclovir, and her condition improved. CMV monitoring is needed when patients develop symptoms related to opportunistic infections during temozolomide treatment for malignant glioma.

Keywords: cytomegalovirus; hemorrhagic cystitis; malignant glioma; temozolomide.

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Figures

Figure 1.
Figure 1.
Magnetic resonance imaging (FLAIR) showed an ill-defined mass in the right frontal lobe of the brain that was pathologically diagnosed as anaplastic oligodendroglioma.
Figure 2.
Figure 2.
Urine cytology (light green staining) showed a large number of neutrophils with a small number of degenerated atypical cells.
See this image and copyright information in PMC

References

    1. Stupp R, Mason WP, Van Den Bent MJ, et al. . Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352: 987-996, 2005. - PubMed
    1. Louis DN, Perry A, Reifenberger G, et al. . The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131: 803-820, 2016. - PubMed
    1. Grossman SA, Ye X, Lesser G, et al. . Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide. Clin Cancer Res 17: 5473-5480, 2011. - PMC - PubMed
    1. Campian JL, Piotrowski AF, Ye X, et al. . Serial changes in lymphocyte subsets in patients with newly diagnosed high grade astrocytomas treated with standard radiation and temozolomide. J Neurooncol 135: 1-9, 2017. - PubMed
    1. Olnes MJ, Kotliarov Y, Biancotto A, et al. . Effects of systemically administered hydrocortisone on the human immunome. Sci Rep 6: 23002, 2016. - PMC - PubMed

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