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Review
. 2018 May 8:12:733-747.
doi: 10.2147/PPA.S162420. eCollection 2018.

Patient-reported outcomes in European spondyloarthritis patients: a systematic review of the literature

Juan Carlos Torre-Alonso  1 , Rubén Queiro  2 , Marta Comellas  3 , Luís Lizán  3   4 , Carles Blanch  5
Affiliations
Review

Patient-reported outcomes in European spondyloarthritis patients: a systematic review of the literature

Juan Carlos Torre-Alonso et al. Patient Prefer Adherence. .

Abstract

Objective: This review aims to summarize the current literature on patient-reported outcomes (PROs) in spondyloarthritis (SpA).

Patients and methods: We performed a systematic literature review to identify studies (original articles and narrative and systematic reviews) regarding PROs (health-related quality of life [HRQoL], satisfaction, preferences, adherence/compliance, and persistence) in SpA patients published in the European Union through December 2016. International databases (Medline/PubMed, Cochrane Library, ISI Web of Knowledge, Scopus) were searched using keywords in English. The methodological quality of the studies was assessed using the Oxford Centre for Evidence-Based Medicine criteria.

Results: A total of 26 publications met the inclusion criteria. Generally, studies indicated that SpA has a negative impact on patients' HRQoL. In patients with ankylosing spondylitis, physical domains were more affected than emotional ones, whereas for psoriatic arthritis, both physical and psychological factors were strongly affected by the disease. Data indicated that biological agents (BAs) greatly contributed to improvement in HRQoL in both ankylosing spondylitis and psoriatic arthritis patients. Findings on compliance with BAs were heterogeneous. However, persistence rates exceeded 50% irrespective of the BA administered. Results on preferences indicated that most SpA patients prefer being involved in decisions regarding their treatment and that besides efficacy and safety, frequency and route of administration may influence patients' preferences for BAs.

Conclusion: Implementing management programs for SpA patients focuses on the physical, emotional, and social consequences of the disease, in addition to assessing and including patient preferences in the treatment decision-making process, could be crucial to improve patients' HRQoL and ensure their satisfaction and compliance with treatment.

Keywords: European Union; ankylosing spondylitis; patient-reported outcomes; psoriatic arthritis; spondyloarthritis; systematic review.

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Conflict of interest statement

Disclosure This study was funded by Novartis Farmacéutica SA. CB works for Novartis Farmacéutica SA. MC and LL work for an independent research entity that received remuneration for development of the original research and writing this manuscript. The remaining authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flowchart of study selection according to PRISMA. Abbreviation: PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
See this image and copyright information in PMC

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