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. 2018 May;6(2):101-107.
doi: 10.1093/gastro/gox036. Epub 2017 Nov 8.

Outcomes and prognostic factors of fecal microbiota transplantation in patients with slow transit constipation: results from a prospective study with long-term follow-up

Chao Ding  1   2 , Wenting Fan  3 , Lili Gu  2 , Hongliang Tian  2 , Xiaolong Ge  2 , Jianfeng Gong  2 , Yongzhan Nie  4 , Ning Li  2   5
Affiliations

Outcomes and prognostic factors of fecal microbiota transplantation in patients with slow transit constipation: results from a prospective study with long-term follow-up

Chao Ding et al. Gastroenterol Rep (Oxf). 2018 May.

Abstract

Background and aim: Gut microbiota may contribute to regulate colonic motility, which is involved in the etiology of constipation. Fecal microbiota transplantation (FMT) has been demonstrated to restore intestinal homeostasis. The aim of this study was to evaluate the clinical outcomes and prognostic factors of FMT for the treatment of slow transit constipation (STC).

Methods: Fifty-two patients with STC received standardized FMT and were followed up for 6 months. Bowel habit, colonic transit time, constipation-related symptoms (PAC-SYM score), quality of life (PAC-QOL score), treatment satisfaction scores and adverse events were monitored. The primary efficacy endpoint was the proportion of patients having on average three or more complete spontaneous bowel movements (CSBMs) per week.

Results: The primary efficacy endpoint was achieved in 50.0%, 38.5% and 32.7% of patients over week intervals 3-4, 9-12 and 21-24, respectively (P < 0.01 for all comparisons). Significant improvements were also observed in other bowel movement assessments, colonic transit time, constipation-related symptoms and quality of life; but all improvements diminished at weeks 12 and 24. Incompleteness of evacuation served as the only factor associated with efficacy. No serious treatment-related adverse events were observed.

Conclusion: This study suggested FMT was effective and safe for STC, while a late loss of efficacy was also observed. A lower degree of sensation of incompleteness predicted a better outcome.

Keywords: Fecal microbiota transplantation; colonic motility; gut microbiota; prognostic factors; slow transit constipation.

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Figures

Figure 1.
Figure 1.
Changes of colonic transit time. (A) Mean colonic transit time in all patients at baseline and weeks 4, 12 and 24. (B) Mean colonic transit time in responders and non-responders at weeks 4, 12 and 24. *P < 0.05; **P < 0.01.
See this image and copyright information in PMC

References

    1. Lembo A, Camilleri M. Chronic constipation. New Engl J Med 2003;349:1360–8. - PubMed
    1. Dennison C, Prasad M, Lloyd A, et al. The health-related quality of life and economic burden of constipation. Pharmacoeconomics 2005;23:461–76. - PubMed
    1. Irvine EJ, Ferrazzi S, Pare P, et al. Health-related quality of life in functional GI disorders: focus on constipation and resource utilization. Am J Gastroenterol 2002;97:1986–93. - PubMed
    1. Bharucha AE, Dorn SD, Lembo A, et al. American Gastroenterological Association medical position statement on constipation. Gastroenterology 2013;144:211–17. - PubMed
    1. Bharucha AE, Pemberton JH, Locke III GR. American Gastroenterological Association technical review on constipation. Gastroenterology 2013;144:218–38. - PMC - PubMed

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