Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Jan 28:10:16-17.
doi: 10.1016/j.ajoc.2018.01.035. eCollection 2018 Jun.

Morning glory disc anomaly and ipsilateral sporadic optic pathway glioma

Affiliations
Case Reports

Morning glory disc anomaly and ipsilateral sporadic optic pathway glioma

Michael Kinori et al. Am J Ophthalmol Case Rep. .

Abstract

Purpose: To present a rare case of morning glory disc anomaly in association with an ipsilateral low grade glioma.

Observations: A 5 year old male presented with a unilateral morning glory disc anomaly and an ipsilateral sporadic optic pathway glioma with chiasmal involvement. After a strict patching regimen his vision improved from 20/400 to 20/80.

Conclusions and importance: This report strengthens the recommendation for brain magnetic resonance imaging in patients with morning glory disc anomaly. Patching of the contralateral eye should be attempted since the role of amblyopia may be significant.

Keywords: Amblyopia; Magnetic resonance imaging; Morning glory disc anomaly; Optic pathway glioma.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Fundus photos of both eyes. The optic nerve in the right eye is markedly enlarged and has a funnel-shaped excavation. Retinal vessels emanate radially beyond a central core, and the disc itself is encircled by a partially elevated region of chorioretinal pigmentation and atrophy. This is compatible with morning glory disc anomaly. The left optic nerve and macula are normal.
Fig. 2
Fig. 2
Magnetic resonance images of the brain and orbits. (a) Axial T1-weighted image showing expansion of the right prechiasmatic optic nerve. (b) Coronal T2-weighted image showing enlargement of the right optic nerve and right lateral aspect of the optic chiasm with increased T2 signal (c) Coronal T1-weighted image after gadolinium injection showing minimal, thin enhancement along the margin of the lesion. White arrows indicate the right optic nerve.

References

    1. Lee B.J., Traboulsi E.I. Update on the morning glory disc anomaly. Ophthalmic Genet. 2008;29:47–52. - PubMed
    1. Bandopadhayay P., Dagi L., Robison N., Goumnerova L., Ullrich N.J. Morning glory disc anomaly in association with ipsilateral optic nerve glioma. Arch Ophthalmol. 2012;130:1082–1083. - PubMed
    1. Azuma N., Yamaguchi Y., Handa H. Mutations of the PAX6 gene detected in patients with a variety of optic-nerve malformations. Am J Hum Genet. 2003;72:1565–1570. - PMC - PubMed
    1. Harasymowycz P., Chevrette L., Decarie J.C. Morning glory syndrome: clinical, computerized tomographic, and ultrasonographic findings. J Pediatr Ophthalmol Strabismus. 2005;42:290–295. - PubMed
    1. Lenhart P.D., Lambert S.R., Newman N.J. Intracranial vascular anomalies in patients with morning glory disk anomaly. Am J Ophthalmol. 2006;142:644–650. - PubMed

Publication types

LinkOut - more resources