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. 2019 Dec;33(23):3357-3363.
doi: 10.1080/14786419.2018.1477149. Epub 2018 May 21.

Anti-proliferative diterpenes from Dacrycarpus imbricatus

Nguyen Thanh Tam  1   2 , Tran Duc Quan  1 , Dang Viet Hau  2 , Nguyen Thi Hoang Anh  1   2 , Thi Thanh Thuy Tran  2 , Nguyen Hoang Sa  2   3 , Dao Duc Thien  1 , Le Thi Hong Nhung  4 , Dinh Thi Phong  5 , Sabrina Adorisio  6 , Domenico V Delfino  6 , Trinh Thi Thuy  1   2
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Anti-proliferative diterpenes from Dacrycarpus imbricatus

Nguyen Thanh Tam et al. Nat Prod Res. 2019 Dec.

Abstract

A new diterpene, cassipouryl hexadecanoate (2), in addition to the cassipourol (1) and four terpenes (3-6) were isolated from the twigs and leaves of Dacrycarpus imbricatus (Blume) de Laub. The structures of the two monocyclic diterpenes (1, 2), were elucidated on the basic of 1D and 2D NMR spectroscopic data and compared with the literature. These two monocyclic diterpenes (1, 2) were tested for their anti-proliferative activity on acute myeloid leukemia (OCI-AML) cells. The results showed that 1 had significantly anti-proliferative activity whereas 2 was weakly active.

Keywords: acute myeloid leukemia; anti-proliferative; cassipourol; cassipouryl hexadecanoate.

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