Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells

Jon Odorico¹, James Markmann², Douglas Melton³, Julia Greenstein⁴, Albert Hwa⁵, Cristina Nostro⁶, Alireza Rezania⁷, Jose Oberholzer⁸, Daniel Pipeleers⁹, Luhan Yang¹⁰, Chad Cowan¹¹, Danwei Huangfu¹², Dieter Egli¹³, Uri Ben-David¹⁴, Ludovic Vallier¹⁵, Shane T Grey¹⁶, Qizhi Tang¹⁷, Bart Roep¹⁸, Camilo Ricordi¹⁹, Ali Naji²⁰, Giuseppe Orlando²¹, Daniel G Anderson²², Mark Poznansky²³, Barbara Ludwig²⁴, Alice Tomei¹⁹, Dale L Greiner²⁵, Melanie Graham²⁶, Melissa Carpenter²⁷, Giovanni Migliaccio²⁸, Kevin D'Amour⁷, Bernhard Hering²⁶, Lorenzo Piemonti²⁹, Thierry Berney³⁰, Mike Rickels²⁰, Thomas Kay³¹, Ann Adams²

Affiliations

¹ Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
² Department of Surgery, Massachusetts General Hospital, Boston, MA.
³ Harvard Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Boston MA.
⁴ Juvenile Diabetes Research Foundation, New York, NY.
⁵ Joslin Diabetes Center, Harvard Medical School, Boston, MA.
⁶ Department of Physiology, University of Toronto, University of Toronto, Toronto Canada.
⁷ ViaCyte, Inc., San Diego, CA.
⁸ Department of Surgery, University of Illinois at Chicago, Chicago, IL.
⁹ Center for Beta Cell Therapy in Diabetes, Vrije Universiteit Brussel, Brussels, Belgium.
¹⁰ eGenesis, Inc., Cambridge MA.
¹¹ Harvard Stem Cell Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
¹² Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY.
¹³ Columbia Stem Cell Initiative, Columbia University, New York, NY.
¹⁴ Broad Institute of MIT and Harvard, Cancer Program, Golub Lab, Cambridge MA.
¹⁵ Department of Surgery, University of Cambridge, Cambridge, United Kingdom.
¹⁶ Department of Medicine, University of Sydney, Sydney, Australia.
¹⁷ Department of Surgery, UCSF Medical Center, San Francisco, CA.
¹⁸ National Diabetes Center of Excellence, Leiden University Medical Center, Leiden, The Netherlands.
¹⁹ Department of Surgery, University of Miami, Miami, FL.
²⁰ Department of Surgery, University of Pennsylvania, Philadelphia, PA.
²¹ Center on Diabetes, Obesity, and Metabolism, Wake Forest School of Medicine, Winston-Salem, NC.
²² Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA.
²³ Department of Medicine, Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
²⁴ Department of Endocrinology and Diabetes, University Hospital Dresden, Dresden, Germany.
²⁵ Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA.
²⁶ Department of Surgery, University of Minnesota, Minneapolis, MN.
²⁷ Carpenter Group Consulting, Seattle, WA.
²⁸ European Infrastructure for Translational Medicine, Amsterdam Netherlands.
²⁹ Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan Italy.
³⁰ Department of Surgery, Geneva University, Geneva, Switzerland.
³¹ Department of Medicine, St. Vincent's Institute, Melbourne, Australia.

PMID: 29781950
PMCID: PMC6775764
DOI: 10.1097/TP.0000000000002217

Review

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells

Jon Odorico et al. Transplantation. 2018 Aug.

. 2018 Aug;102(8):1223-1229.

doi: 10.1097/TP.0000000000002217.

Authors

Affiliations

¹ Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
² Department of Surgery, Massachusetts General Hospital, Boston, MA.
³ Harvard Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Boston MA.
⁴ Juvenile Diabetes Research Foundation, New York, NY.
⁵ Joslin Diabetes Center, Harvard Medical School, Boston, MA.
⁶ Department of Physiology, University of Toronto, University of Toronto, Toronto Canada.
⁷ ViaCyte, Inc., San Diego, CA.
⁸ Department of Surgery, University of Illinois at Chicago, Chicago, IL.
⁹ Center for Beta Cell Therapy in Diabetes, Vrije Universiteit Brussel, Brussels, Belgium.
¹⁰ eGenesis, Inc., Cambridge MA.
¹¹ Harvard Stem Cell Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
¹² Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY.
¹³ Columbia Stem Cell Initiative, Columbia University, New York, NY.
¹⁴ Broad Institute of MIT and Harvard, Cancer Program, Golub Lab, Cambridge MA.
¹⁵ Department of Surgery, University of Cambridge, Cambridge, United Kingdom.
¹⁶ Department of Medicine, University of Sydney, Sydney, Australia.
¹⁷ Department of Surgery, UCSF Medical Center, San Francisco, CA.
¹⁸ National Diabetes Center of Excellence, Leiden University Medical Center, Leiden, The Netherlands.
¹⁹ Department of Surgery, University of Miami, Miami, FL.
²⁰ Department of Surgery, University of Pennsylvania, Philadelphia, PA.
²¹ Center on Diabetes, Obesity, and Metabolism, Wake Forest School of Medicine, Winston-Salem, NC.
²² Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA.
²³ Department of Medicine, Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
²⁴ Department of Endocrinology and Diabetes, University Hospital Dresden, Dresden, Germany.
²⁵ Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA.
²⁶ Department of Surgery, University of Minnesota, Minneapolis, MN.
²⁷ Carpenter Group Consulting, Seattle, WA.
²⁸ European Infrastructure for Translational Medicine, Amsterdam Netherlands.
²⁹ Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan Italy.
³⁰ Department of Surgery, Geneva University, Geneva, Switzerland.
³¹ Department of Medicine, St. Vincent's Institute, Melbourne, Australia.

PMID: 29781950
PMCID: PMC6775764
DOI: 10.1097/TP.0000000000002217

Abstract

Beta cell replacement has the potential to restore euglycemia in patients with insulin-dependent diabetes. Although great progress has been made in establishing allogeneic islet transplantation from deceased donors as the standard of care for those with the most labile diabetes, it is also clear that the deceased donor organ supply cannot possibly treat all those who could benefit from restoration of a normal beta cell mass, especially if immunosuppression were not required. Against this background, the International Pancreas and Islet Transplant Association in collaboration with the Harvard Stem Cell Institute, the Juvenile Diabetes Research Foundation (JDRF), and the Helmsley Foundation held a 2-day Key Opinion Leaders Meeting in Boston in 2016 to bring together experts in generating and transplanting beta cells derived from stem cells. The following summary highlights current technology, recent significant breakthroughs, unmet needs and roadblocks to stem cell-derived beta cell therapies, with the aim of spurring future preclinical collaborative investigations and progress toward the clinical application of stem cell-derived beta cells.

PubMed Disclaimer

Conflict of interest statement

The authors declare no funding or conflicts of interest.

Comment in

Gearing Up for Stem Cell-derived Beta Cells-Are We Ready?
Shapiro AMJ. Shapiro AMJ. Transplantation. 2018 Aug;102(8):1207-1208. doi: 10.1097/TP.0000000000002214. Transplantation. 2018. PMID: 29677076 No abstract available.

References

1. Rezania A, Bruin JE, Arora P, et al. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat Biotechnol. 2014;32:1121–1133. - PubMed
1. Pagliuca FW, Millman JR, Gürtler M, et al. Generation of functional human pancreatic β cells in vitro. Cell. 2014;159:428–439. - PMC - PubMed
1. Russ HA, Parent AV, Ringler JJ, et al. Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro. EMBO J. 2015;34:1759–1772. - PMC - PubMed
1. Bruin JE, Rezania A, Kieffer TJ. Replacing and safeguarding pancreatic β cells for diabetes. Sci Transl Med. 2015;7:316ps23. - PubMed
1. Kieffer TJ. Closing in on Mass Production of Mature Human Beta Cells. Cell Stem Cell. 2016;18:699–702. - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells

Affiliations

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells

Authors

Affiliations

Abstract

Conflict of interest statement

Comment in

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical