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. 2017;1(1):7.
doi: 10.1186/s41824-017-0014-y. Epub 2017 Dec 15.

Somatostatin receptor based hybrid imaging in sarcoidosis

Riemer H J A Slart  1 , Klaas-Pieter Koopmans  2 , Peter Paul van Geel  3 , Henk Kramer  4 , Harry J M Groen  5 , C Tji-Joong Gan  5 , Niek H J Prakken  1 , Andor W J M Glaudemans  1 , George D Nossent  5
Affiliations

Somatostatin receptor based hybrid imaging in sarcoidosis

Riemer H J A Slart et al. Eur J Hybrid Imaging. 2017.

Abstract

Several diagnostic imaging methodologies are available for the clinical evaluation of sarcoidosis, but all have their limitations. FDG PET/CT is frequently used, but this technique does not provide optimal results in all cases. Novel radiopharmaceuticals aimed at other disease targets may be helpful, particularly in cardiac sarcoidosis when FDG PET/CT has a low diagnostic accuracy, due to difficulties in preparing the patients who should use a specific diet combined with prolonged fasting. 68Ga-labeled somatostatin based receptor hybrid imaging is a potential alternative to FDG PET/CT. This short communication provides a rapid overview of initial findings concerning the application of 68Ga-labeled somatostatin based receptor hybrid imaging in the diagnosis of (cardiac) sarcoidosis activity.

Keywords: Cardiac; PET/CT; Sarcoidosis; Somatostatin receptor imaging.

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Conflict of interest statement

Informed consent was not required (since this is a retrospective study).The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
68Ga-Dotatoc whole body PET (a) in a 56-year old woman with chronic (cardiac) sarcoidosis. Increased uptake is visible in the lymph nodes located at the right-sideof the mediastinum and in lung hilar tissue. 68Ga-Dotatoc PET/CT uptake (b) is visible in the left ventricle of the heart (lateral, basal, septal) and the anterior part of the right ventricle. The same distribution pattern is visible on FDG whole body (c) and cardiac PET (d), but is more intense. Apparently FDG PET was more helpful than 68Ga-Dotatoc in the chronic phase of sarcoidosis in this patient
See this image and copyright information in PMC

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