Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 May 21;18(1):177.
doi: 10.1186/s12884-018-1796-z.

Short term sequelae of preeclampsia: a single center cohort study

Michael Girsberger  1 , Catherine Muff  2 , Irene Hösli  2 , Michael Jan Dickenmann  3
Affiliations

Short term sequelae of preeclampsia: a single center cohort study

Michael Girsberger et al. BMC Pregnancy Childbirth. .

Abstract

Background: Data on the prevalence of persistent symptoms in the first year after preeclampsia are limited. Furthermore, possible risk factors for these sequelae are poorly defined. We investigated kidney function, blood pressure, proteinuria and urine sediment in women with preeclampsia 6 months after delivery with secondary analysis for possible associated clinical characteristics.

Methods: From January 2007 to July 2014 all women with preeclampsia and 6-months follow up at the University Hospital Basel were analyzed. Preeclampsia was defined as new onset of hypertension (≥140/90 mmHg) and either proteinuria or signs of end-organ dysfunction. Hypertension was defined as a blood pressure ≥ 140/90 mmHg or the use of antihypertensive medication. Proteinuria was defined as a protein-to-creatinine ratio in a spot urine > 11 mg/mmol. Urine sediment was evaluated by a nephrologist. Secondary analyses were performed to investigate for possible parameters associated with persistent symptoms after preeclampsia.

Results: Two hundred two women were included into the analysis. At a mean time of follow up of 172 days (+/- 39.6) after delivery, mean blood pressure was 124/76 mmHg (+/- 14/11, range 116-182/63-110) and the mean serum-creatinine was 61.8 μmol/l (33-105 μmol/l) (normal < 110 μmol/l). Mean estimated glomerular filtration rate using CKD-EPI was 110.7 mml/min/1.73m2 (range 59.7-142.4 mml/min/1.73m2) (normal > 60 mml/min/1.73m2). 20.3% (41/202) had a blood pressure of 140/90 mmHg or higher (mean 143/89 mmHg) or were receiving antihypertensive medication (5.5%, 11/202). Proteinuria was present in 33.1% (66/199) (mean 27.5 mg/mmol). Proteinuria and hypertension was present in 8% (16/199). No active urine sediment (e.g. signs of glomerulonephritis) was observed. Age and gestational diabetes were associated with persistent proteinuria and severe preeclampsia with eGFR decline of ≥ 10 ml/min/1.73m2.

Conclusion: Hypertension and proteinuria are common after 6 months underlining the importance of close follow up to identify those women who need further care.

Keywords: Follow-up; Preeclampsia; Sequelae.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the Swiss Ethic Committee of northwest and central Switzerland as part of the swissethics association to be conducted under Art. 34 HFG, ART. 37-40 HFV of Swiss Federal Law waiving the need for consent.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
a and b Distribution of urinary protein excretion and blood pressure at follow-up
Fig. 2
Fig. 2
Prevalence of hypertension, proteinuria and eGFR decline at mean follow-up of 172 days (± 39.6) after delivery
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2013;170:1–7. doi: 10.1016/j.ejogrb.2013.05.005. - DOI - PubMed
    1. Vikse BE, Irgens LM, Bostad L, Iversen BM. Adverse perinatal outcome and later kidney biopsy in the mother. J Am Soc Nephrol. 2006;17:837–845. doi: 10.1681/ASN.2005050492. - DOI - PubMed
    1. Wang I-K, Muo C-H, Chang Y-C, Liang C-C, Chang C-T, Lin S-Y, et al. Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study. CMAJ. 2013;185:207–213. doi: 10.1503/cmaj.120230. - DOI - PMC - PubMed
    1. Vikse BE, Irgens LM, Leivestad T, Skjaerven R, Iversen BM. Preeclampsia and the risk of end-stage renal disease. N Engl J Med. 2008;359:800–809. doi: 10.1056/NEJMoa0706790. - DOI - PubMed
    1. Chesley LC, Annitto JE, Cosgrove RA. American journal of obstetrics and gynecology, volume 124, 1976: the remote prognosis of eclamptic women. Sixth periodic report. Am J Obstet Gynecol. 2000;182 1 Pt 1:247. doi: 10.1016/S0002-9378(00)70520-5. - DOI - PubMed

MeSH terms