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. 2018 May 21;18(1):46.
doi: 10.1186/s12894-018-0364-1.

Posterior urethral valves: 10 years audit of epidemiologic, diagnostic and therapeutic aspects in Yaoundé gynaeco-obstetric and paediatric hospital

Faustin Felicien Mouafo Tambo  1   2 , Paul Nkemtendong Tolefac  3 , Marcelin Ngowe Ngowe  4 , Jacqueline Ze Minkande  5   6 , Landry Mbouche  2 , Georgette Guemkam  7 , Neville Alemnju Telelen  4 , Fru Fobuzshi Angwafo 3rd  1   2 , Aurelien Maurice Sosso  1
Affiliations

Posterior urethral valves: 10 years audit of epidemiologic, diagnostic and therapeutic aspects in Yaoundé gynaeco-obstetric and paediatric hospital

Faustin Felicien Mouafo Tambo et al. BMC Urol. .

Abstract

Background: The incidence of posterior urethral valve (PUV) is estimated at 1:5000-1:8000 males. It is the most common paediatric urologic urgency and the most common cause of male obstructive uropathy and chronic renal failure in children. The study aimed to describe the experience of Yaoundé gynaeco-obstetrics and paediatric hospital in the management of PUV.

Methods: Retrospectively, medical records were retrieved over a ten year period and all data recorded and analyzed for study objectives. Patients were called and evaluated for outcomes regarding morbidity and mortality.

Results: A total of 18 patients all males were managed over the ten year period, given prevalence of 13 cases/100,000 admissions and an admission rate of 2 per annum. The median age at presentation was 22 months and 13 (72.2%) participants presented late. Voiding urethrocystogram was done in all the participants where it showed dilated and elongated posterior urethral valves in 16 (88.9%) of the cases. Endoscopic valve ablation resulted in the relief of obstruction in all but 3 (16.7%) participants that had residual valves and 2 (11.2%) participants that had urethral stenosis. Type I valves were most common in 14 (78.0%) participants. The mean duration of follow up was 34.56 ± 21.47 months. Complications at final follow up were: 10 (55.6%) chronic renal failure, 2 (11.2%) end-stage renal failure. The case fatality rate was 5.6%.

Conclusion: Many patients present late in our setting with already established complications. There is the need to counsel parents/guardians on the importance of long-term follow up after relief of obstruction.

Keywords: Diagnostic; Epidemiologic; Late presentation; Posterior urethral valves; Yaoundé.

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Conflict of interest statement

Ethics approval and consent to participate

Two ethical clearances were obtained from the ethical committee Yaoundé Gynaeco-Obstetric and Paediatric Hospital (Reference No: 267/CIERSH/DM/2015) and the Institutional review board of the University of Douala (IEC-UD/443/02/2016/T). Written consent for participation was obtained from the patient’s guardians or parents.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Bacteria isolated in the urine of patients
Fig. 2
Fig. 2
VCUG showing dilated and elongated PUV (White arrow) in a 2 year 3 months old toddler
Fig. 3
Fig. 3
Variations of GFR before surgery (blue) and at final follow up (red) for 9 patients
See this image and copyright information in PMC

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