Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 May 22;137(21):2274-2277.
doi: 10.1161/CIRCULATIONAHA.117.032626.

Raising NAD in Heart Failure: Time to Translate?

Matthew A Walker  1 , Rong Tian  2
Affiliations
Editorial

Raising NAD in Heart Failure: Time to Translate?

Matthew A Walker et al. Circulation. .
No abstract available

Keywords: Editorials; NAD; heart failure; nicotinamide riboside.

PubMed Disclaimer

Figures

Figure 1
Figure 1
NAD+ biosynthesis, consumption and salvage pathways. The intracellular NAD+ pool consists of both oxidized (NAD+) and reduced (NADH) forms. Electrons derived from substrate catabolism are carried by NADH and used for oxidative phosphorylation and biosynthetic reactions. NAD+ also functions as a co-substrate for sirtuins, ADP-ribose transferases, and cyclic ADP-ribose synthases (CD38). Eukaryotes synthesize NAD+ from the amino acid tryptophan via the de novo pathway or NAD+ can be salvaged from nicotinamide (NAM) and converted into nicotinamide mononucleotide (NMN) by nicotinamide phosphoribosyltransferase (Nampt). NMN can also be generated by the phosphorylation of NR by nicotinamide riboside kinase (Nrk).
See this image and copyright information in PMC

Comment on

References

    1. Ussher JR, Jaswal JS, Lopaschuk GD. Pyridine nucleotide regulation of cardiac intermediary metabolism. Circ Res. 2012;111:628–641. - PubMed
    1. Canto C, Menzies KJ, Auwerx J. NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab. 2015;22:31–53. - PMC - PubMed
    1. Lee CF, Tian R. Mitochondrion as a Target for Heart Failure Therapy- Role of Protein Lysine Acetylation. Circ J. 2015;79:1863–1870. - PubMed
    1. Wang W, Karamanlidis G, Tian R. Novel targets for mitochondrial medicine. Sci Transl Med. 2016;8:326rv3. - PMC - PubMed
    1. Diguet Nicolas, Trammell Samuel AJ, Tannous Cynthia, Deloux Robin, Piquereau Jérôme, Mougenot Nathalie, Gouge Anne, Gressette Mélanie, Manoury Boris, Blanc Jocelyne, Breton Marie, Decaux Jean-François, Lavery Gareth, Baczkó István, Zoll Joffrey, Garnier Anne, Li Zhenlin, Brenner Charles, Mericskay Mathias. Circulation. 2017 CIRCULATIONAHA.116.026099. [In Press] - PMC - PubMed