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. 2018 Jun 1;19(8):707-713.
doi: 10.2217/pgs-2018-0027. Epub 2018 May 22.

Variants in genes coding for glutathione S-transferases and asthma outcomes in children

Steve Turner  1 , Ben Francis  2 , Nuha Wani  1 , Susanne Vijverberg  3   4 , Maria Pino-Yanes  5 , Somnath Mukhopadhyay  6   7 , Roger Tavendale  7 , Colin Palmer  7 , Esteban G Burchard  8   9 , Simon Kebede Merid  10 , Erik Melén  10   11 , Anke H Maitland-van der Zee  3   4 , On Behalf Of The Pharmacogenomics In Childhood Asthma Consortium
Affiliations

Variants in genes coding for glutathione S-transferases and asthma outcomes in children

Steve Turner et al. Pharmacogenomics. .

Abstract

Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.

Keywords: asthma; child; exacerbation; glutathione S-transferase; severity; tobacco smoke.

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Conflict of interest statement

Financial & competing interests disclosure

AH Maitland-van der Zee received an unrestricted research grant for research on Pharmacogenomics in childhood asthma from Glaxo Smith Kleine. The contribution from GALA II to this work wassupported by grants from NIH to EG Burchard: The National Heart, Lung and Blood Institute (HL088133, HL078885, HL004464, HL104608 and HL117004); the National Institute of Environmental Health Sciences (ES015794); the National Institute on Minority Health and Health Disparities (MD006902); the National Institute of General Medical Sciences (GM007546). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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