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. 2018 Jun 22;81(6):1405-1410.
doi: 10.1021/acs.jnatprod.8b00015. Epub 2018 May 22.

Cytotoxic and Antibacterial Eremophilane Sesquiterpenes from the Marine-Derived Fungus Cochliobolus lunatus SCSIO41401

Wei Fang  1   2 , Jianjiao Wang  2 , Junfeng Wang  2 , Liqiao Shi  1 , Kunlong Li  2 , Xiuping Lin  2 , Yong Min  1 , Bin Yang  2 , Lan Tang  3 , Yonghong Liu  2 , Xuefeng Zhou  2
Affiliations

Cytotoxic and Antibacterial Eremophilane Sesquiterpenes from the Marine-Derived Fungus Cochliobolus lunatus SCSIO41401

Wei Fang et al. J Nat Prod. .

Abstract

Three new eremophilane sesquiterpenes, dendryphiellins H-J (1-3), and three new phthalide natural products (4-6) were isolated from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Their structures including absolute configurations were determined by spectroscopic and calculated ECD analyses. Dendryphiellin I (2) showed cytotoxic and antibacterial activities against five cancer cell lines (IC50 1.4 to 4.3 μM) and three bacterial species (MIC 1.5 to 13 μg/mL), respectively. Dendryphiellin J (3), a rare naturally occurring aldoxime analogue, displayed cytotoxicities against ACHN and HepG-2 cells with IC50 values of 3.1 and 5.9 μM, respectively. Further studies indicated that 3 induced apoptosis in ACHN cells in a dose- and time-dependent manner.

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