Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review

The Role of the Thyroid in the Developing Heart

Kazuhiro Maeda  1 , Sachiko Miyagawa-Tomita  2 , Toshio Nakanishi  1
Toshio Nakanishi  1 , Roger R. Markwald  2 , H.Scott Baldwin  3 , Bradley B. Keller  4 , Deepak Srivastava  5 , Hiroyuki Yamagishi  6
, editors.
In: Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 16.
.
Affiliations
Free Books & Documents
Review

The Role of the Thyroid in the Developing Heart

Kazuhiro Maeda et al.
Free Books & Documents

Excerpt

Congenital hypothyroidism (CH) is one of the most common diseases of the endocrine system among newborns. Infants with CH have been reported to have a high frequency of congenital cardiovascular malformations (CM), such as ventricular and atrial septal defects [1]. Some studies have demonstrated that these cases were due to gene mutations and neural crest abnormality. Infants with CH and CM have been shown to have significantly lower T4 levels than those with isolated CH. However, the role of thyroid hormone in the developing heart has not been reported. In this study, we show the thyroid anlage in chick embryos by immunohistochemistry and follow the expression of thyroid hormone receptor during heart development.

PubMed Disclaimer

Sections

References

    1. Olivieri A, Stazi MA, Mastroiacovo P, et al. A population-based study on the frequency of additional congenital malformations in infants with congenital hypothyroidism: data from the Italian Registry for Congenital Hypothyroidism (1991–1998). J Clin Endocrinol Metab. 2002;87:557–62. - PubMed
    1. Prati M, Calvo R, Morreale G, Morreale de Escobar G. L-thyroxine and 3,5,3′-triiodothyronine concentrations in the chicken egg and in the embryo before and after the onset of thyroid function. Endocrinology. 1992;130:2651–9. - PubMed
    1. Forrest D, Sjöberg M, Vennström B. Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes. EMBO J. 1990;9:1519–28. - PMC - PubMed

LinkOut - more resources