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In: Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 14.
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Affiliations
Affiliation
1 Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka, 565-8565, Japan
Book Affiliations
1 Department of Pediatric Cardiology, Tokyo Women's Medical University, Tokyo, Japan
2 Cardiovascular Developmental Biology Center, Medical University of South Carolina Clemson University, Charleston, South Carolina, USA
3 Department of Pediatrics (Cardiology), Vanderbilt University, Nashville, Tennessee, USA
4 Pediatrics, Pharmacology and Toxicology, and Bioengineering, University of Louisville, Louisville, Kentucky, USA
5 Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
6 Pediatrics, Division of Pediatric Cardiology, Keio University School of Medicine, Tokyo, Japan
S1P-S1p2 Signaling in Cardiac Precursor Cells Migration
Hajime Fukui et al.
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In: Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 14.
During embryogenesis, zebra fish cardiac precursor cells (CPCs) originating from anterior lateral plate mesoderm migrate toward the midline between the endoderm and the yolk syncytial layer (YSL) to form cardiac tube. The endoderm functions as a foothold for CPCs as evidenced by the endodermal mutants (cas/sox32, sox17, oep, fau/gata5, and bon) showing two hearts (cardia bifida) [1]. Furthermore, mutant zebra fish (toh) lacking sphingosine-1-phosphate (S1P) transporter which is expressed in the YSL show two hearts [2], indicating the essential role for S1P-mediated signal in cardiac development. This is also supported by a S1p2 receptor mutant (mil) which exhibits two hearts [3]. However, it is still unclear how S1P released from YSL regulates CPC migration.
Kikuchi Y, et al. casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish. Genes Dev. 2001;15(12):1493–505.
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Kawahara A, et al. The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. Science. 2009;323(5913):524–7.
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Kupperman E, et al. A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development. Nature. 2000;406:192–5.
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Ye D, Lin F. S1pr2/Gα13 signaling controls myocardial migration by regulating endoderm convergence. Development. 2013;140:789–99.
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Yu FX, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012;150(4):780–91.
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