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Review

Modification of Cardiac Phenotype in Tbx1 Hypomorphic Mice

Takatoshi Tsuchihashi  1 , Reina Ishizaki  1 , Jun Maeda  1 , Akimichi Shibata  1 , Keiko Uchida  1 , Deepak Srivastava  2   3 , Hiroyuki Yamagishi  1
Toshio Nakanishi  1 , Roger R. Markwald  2 , H.Scott Baldwin  3 , Bradley B. Keller  4 , Deepak Srivastava  5 , Hiroyuki Yamagishi  6
, editors.
In: Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 28.
.
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Review

Modification of Cardiac Phenotype in Tbx1 Hypomorphic Mice

Takatoshi Tsuchihashi et al.
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Excerpt

Congenital heart disease is still the leading cause of death within the first year of life. Our lab forces on understanding the morphology of congenital heart disease. Outflow tract anomalies, including abnormal alignment or septation, account for 30 % of all congenital heart disease. To solve the developmental problem of these defects, we are interested in the role of the second heart field (SHF) that gives rise to the outflow tract structure.

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References

    1. Yamagishi H, Maeda J, Hu T, et al. Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Gene Dev. 2003;17:269–81. - PMC - PubMed
    1. Hu T, Yamagishi H, Maeda J, et al. Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development. 2005;131:5491–502. - PubMed

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