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Review

Inositol Trisphosphate Receptors in the Vascular Development

Keiko Uchida  1   2 , Maki Nakazawa  1 , Chihiro Yamagishi  1 , Katsuhiko Mikoshiba  3   4 , Hiroyuki Yamagishi  1
Toshio Nakanishi  1 , Roger R. Markwald  2 , H.Scott Baldwin  3 , Bradley B. Keller  4 , Deepak Srivastava  5 , Hiroyuki Yamagishi  6
, editors.
In: Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 32.
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Review

Inositol Trisphosphate Receptors in the Vascular Development

Keiko Uchida et al.
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Excerpt

The placental circulation is crucial for the development of mammalian embryos [1]. The labyrinth layer in the placenta is created by extensive villous branching of the trophoblast and vascularization arising from the embryonic mesoderm. In the labyrinth, materials are exchanged between the maternal and embryonic circulation. Recently, we have found that inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) may be required for the placental vascularization.

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References

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    1. Uchida K, Aramaki M, Nakazawa M, Yamagishi C, Makino S, et al. Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis. PLoS One. 2010;5:e12500. - PMC - PubMed
    1. Nakamura Y, Hamada Y, Fujiwara T, Enomoto H, Hiroe T, et al. Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development. Mol Cell Biol. 2005;25:10979–88. - PMC - PubMed

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