Chromosome Biology: The Smc-Kleisin Enzymology Finally Comes of Age
- PMID: 29787727
- DOI: 10.1016/j.cub.2018.03.056
Chromosome Biology: The Smc-Kleisin Enzymology Finally Comes of Age
Abstract
Cohesin and condensin are Smc-kleisin complexes responsible for shaping our chromosomes. Despite extensive genetic and genomic information available on their function, their biochemistry has been hard to study. Two recent studies finally bring exciting new insights into their enzymology.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Comment on
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Establishment of DNA-DNA Interactions by the Cohesin Ring.Cell. 2018 Jan 25;172(3):465-477.e15. doi: 10.1016/j.cell.2017.12.021. Epub 2018 Jan 18. Cell. 2018. PMID: 29358048 Free PMC article.
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Real-time imaging of DNA loop extrusion by condensin.Science. 2018 Apr 6;360(6384):102-105. doi: 10.1126/science.aar7831. Epub 2018 Feb 22. Science. 2018. PMID: 29472443 Free PMC article.
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