doi: 10.1016/j.jneumeth.2018.05.013.
Epub 2018 May 19.
Intraepidermal nerve fibres are not the exclusive tranducers of nociception
Affiliations
- PMID: 29787776
- DOI: 10.1016/j.jneumeth.2018.05.013
Item in Clipboard
Intraepidermal nerve fibres are not the exclusive tranducers of nociception
J Neurosci Methods.
.
Abstract
The goal of this article is to provide an insight of the most recent data on cutaneous nociception. Indeed recent studies have demonstrated that keratinocytes closely participate in sensory transduction, and therefore, intraepidermal free nerve endings are not exclusive transducers of pain. Therefore, the results of neurophysiological studies should be interpreted in the light of this information.
Keywords: Electrodes; Free nerve endings; Keratinocytes; Pain; Stimulation.
Copyright © 2018 Elsevier B.V. All rights reserved.
Similar articles
-
What about physical contacts between epidermal keratinocytes and sensory neurons?Exp Dermatol. 2018 Jan;27(1):9-13. doi: 10.1111/exd.13411. Epub 2017 Oct 19. Exp Dermatol. 2018. PMID: 28767170 Review.
-
Cutaneous nociception: Role of keratinocytes.Exp Dermatol. 2019 Dec;28(12):1466-1469. doi: 10.1111/exd.13975. Epub 2019 Jun 24. Exp Dermatol. 2019. PMID: 31125475
-
Intra-epidermal nerve endings progress within keratinocyte cytoplasmic tunnels in normal human skin.Exp Dermatol. 2020 Apr;29(4):387-392. doi: 10.1111/exd.14081. Epub 2020 Feb 14. Exp Dermatol. 2020. PMID: 32003039
-
Interaction of human keratinocytes and nerve fiber terminals at the neuro-cutaneous unit.Elife. 2024 Jan 16;13:e77761. doi: 10.7554/eLife.77761. Elife. 2024. PMID: 38225894 Free PMC article.
-
Anatomical contacts between sensory neurons and epidermal cells: an unrecognized anatomical network for neuro-immuno-cutaneous crosstalk.Br J Dermatol. 2023 Feb 10;188(2):176-185. doi: 10.1093/bjd/ljac066. Br J Dermatol. 2023. PMID: 36763869 Review.
Cited by
-
Neuromodulation of the Autonomic Nervous System in Chronic Low Back Pain: A Randomized, Controlled, Crossover Clinical Trial.Biomedicines. 2023 May 26;11(6):1551. doi: 10.3390/biomedicines11061551. Biomedicines. 2023. PMID: 37371646 Free PMC article.
-
Merkel Cells Are Multimodal Sensory Cells: A Review of Study Methods.Cells. 2022 Nov 29;11(23):3827. doi: 10.3390/cells11233827. Cells. 2022. PMID: 36497085 Free PMC article. Review.
-
Lifting the veil on the keratinocyte contribution to cutaneous nociception.Protein Cell. 2020 Apr;11(4):239-250. doi: 10.1007/s13238-019-00683-9. Epub 2020 Jan 6. Protein Cell. 2020. PMID: 31907794 Free PMC article. Review.
-
Role of Keratinocytes in Sensitive Skin.Front Med (Lausanne). 2019 May 21;6:108. doi: 10.3389/fmed.2019.00108. eCollection 2019. Front Med (Lausanne). 2019. PMID: 31165070 Free PMC article. Review.
-
Pain in Atopic Dermatitis: An Online Population-based Survey.Acta Derm Venereol. 2020 Jul 2;100(14):adv00198. doi: 10.2340/00015555-3521. Acta Derm Venereol. 2020. PMID: 32424431 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
