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. 2018 Aug:117:339-347.
doi: 10.1016/j.envint.2018.05.019. Epub 2018 May 19.

Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3 years

Ann M Vuong  1 , Joseph M Braun  2 , Glenys M Webster  3 , R Thomas Zoeller  4 , Andrew N Hoofnagle  5 , Andreas Sjödin  6 , Kimberly Yolton  7 , Bruce P Lanphear  3 , Aimin Chen  8
Affiliations

Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3 years

Ann M Vuong et al. Environ Int. 2018 Aug.

Abstract

Background: Polybrominated diphenyl ethers (PBDEs) reduce serum thyroid hormone concentrations in animal studies, but few studies have examined the impact of early-life PBDE exposures on thyroid hormone disruption in childhood.

Methods: We used data from 162 mother-child pairs from the Health Outcomes and Measures of the Environment Study (2003-2006, Cincinnati, OH). We measured PBDEs in maternal serum at 16 ± 3 weeks gestation and in child serum at 1-3 years. Thyroid hormones were measured in serum at 3 years. We used multiple informant models to investigate associations between prenatal and early-life PBDE exposures and thyroid hormone levels at age 3 years.

Results: Prenatal PBDEs were associated with decreased thyroid stimulating hormone (TSH) levels at age 3 years. A 10-fold increase in prenatal ∑PBDEs (BDE-28, -47, -99, -100, and -153) was associated with a 27.6% decrease (95% CI -40.8%, -11.3%) in TSH. A ten-fold increase in prenatal ∑PBDEs was associated with a 0.25 pg/mL (0.07, 0.43) increase in free triiodothyronine (FT3). Child sex modified associations between prenatal PBDEs and thyroid hormones, with significant decrements in TSH among females and decreased free T4 (FT4) in males. Prenatal ∑PBDEs were not associated with TT4, FT4, or total T3.

Conclusions: These findings suggest an inverse relationship between prenatal ∑PBDEs and TSH at 3 years. Associations may be sexually dimorphic, with an inverse relationship between prenatal BDE-47 and -99 and TSH in females and null associations among males.

Keywords: Brominated flame retardants; Endocrine disruption; Epidemiology; Polybrominated diphenyl ethers (PBDEs); Thyroid function; Thyroid hormones.

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Conflict of interest statement

Competing financial interest declaration

The authors declare they have no competing financial interests.

Figures

Fig. 1
Fig. 1
β-coefficients and 95% CIs from multiple informant models for associations of PBDEs (ng/g lipid) and thyroid hormones at age 3 years. Adjusted by maternal age, race/ethnicity, education, smoking status during pregnancy, alcohol consumption during pregnancy, vitamin use, maternal BMI, parity, maternal serum ΣPCBs, and child sex.
Fig. 2
Fig. 2
β-coefficients and 95% CIs from linear regression models for associations of prenatal PBDEs (ng/g lipid) and thyroid hormones at 3 years by child sex. Adjusted by maternal age, race/ethnicity, education, smoking status during pregnancy, alcohol consumption during pregnancy, vitamin use, maternal BMI, parity, maternal serum ΣPCBs, and child sex.
See this image and copyright information in PMC

References

    1. Alvarez-Pedrerol M, Ribas-Fito N, Torrent M, Carrizo D, Grimalt JO, Sunyer J. Effects of pcbs, p,p'-ddt, p,p'-dde, hcb and beta-hch on thyroid function in preschool children. Occup Environ Med. 2008;65:452–457. - PubMed
    1. Arkoosh MR, Van Gaest AL, Strickland SA, Hutchinson GP, Krupkin AB, Dietrich JP. Alteration of thyroid hormone concentrations in juvenile Chinook salmon (oncorhynchus tshawytscha) exposed to polybrominated diphenyl ethers, bde-47 and bde-99. Chemosphere. 2017;171:1–8. - PubMed
    1. Bansal R, Tighe D, Danai A, Rawn DF, Gaertner DW, Arnold DL, et al. Polybrominated diphenyl ether (de-71) interferes with thyroid hormone action independent of effects on circulating levels of thyroid hormone in male rats. Endocrinology. 2014;155:4104–4112. - PMC - PubMed
    1. Bernal J. Thyroid hormones in brain development and function. In: De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, editors. Endotext. South Dartmouth (MA): 2000. - PubMed
    1. Blanco J, Mulero M, Lopez M, Domingo JL, Sanchez DJ. Bde-99 deregulates bdnf, bcl-2 and the mrna expression of thyroid receptor isoforms in rat cerebellar granular neurons. Toxicology. 2011;290:305–311. - PubMed

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