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Clinical Trial
. 2018 May 18;217(suppl_1):S6-S15.
doi: 10.1093/infdis/jiy020.

The Sierra Leone Trial to Introduce a Vaccine Against Ebola: An Evaluation of rVSV∆G-ZEBOV-GP Vaccine Tolerability and Safety During the West Africa Ebola Outbreak

Mohamed Samai  1 , Jane F Seward  1 , Susan T Goldstein  2 , Barbara E Mahon  2 , Durodami Radcliffe Lisk  1 , Marc-Alain Widdowson  2 , Mohamed I Jalloh  1 , Stephanie J Schrag  2 , Ayesha Idriss  1 , Rosalind J Carter  2 , Peter Dawson  3 , S A S Kargbo  1 , Bailah Leigh  1 , Mohamed Bawoh  1 , Jennifer Legardy-Williams  2 , Gibrilla Deen  1 , Wendy Carr  2 , Amy Callis  2 , Robert Lindblad  3 , James B W Russell  1 , Carey R Petrie  3 , Augustin E Fombah  1 , Brima Kargbo  4 , Wendi McDonald  1 , Olamide D Jarrett  1 , Robert E Walker  5 , Paul Gargiullo  2 , Donald Bash-Taqi  1 , Laura Gibson  5 , Abu Bakarr Fofanah  4 , Anne Schuchat  2 ; STRIVE Study Team
Collaborators, Affiliations
Clinical Trial

The Sierra Leone Trial to Introduce a Vaccine Against Ebola: An Evaluation of rVSV∆G-ZEBOV-GP Vaccine Tolerability and Safety During the West Africa Ebola Outbreak

Mohamed Samai et al. J Infect Dis. .

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] J Infect Dis. 2018 Jul 2;218(3):508-507. doi: 10.1093/infdis/jiy353. J Infect Dis. 2018. PMID: 29982802 Free PMC article. No abstract available.

Abstract

ClinicalTrials.gov [NCT02378753] and Pan African Clinical Trials Registry [PACTR201502001037220].

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Figures

Figure 1.
Figure 1.
Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) consort flow diagram. *More than 1 reason for ineligibility could be selected; the 6 most common reasons are listed. †A total of 4123 participants were vaccinated within 7 days; 42 were vaccinated after 7 days. ǂIncluded in the vaccinated group. §10 with invalid substudy consent; 3 other.
Figure 2.
Figure 2.
Map of Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) study sites, Sierra Leone. Abbreviation: CDC, Centers for Disease Control and Prevention.
See this image and copyright information in PMC

References

    1. Gostin LO, Lucey D, Phelan A. The Ebola epidemic: a global health emergency. JAMA 2014; 312:1095–6. - PubMed
    1. Incident Management System Ebola Epidemiology Team CDC, Guinea Interministerial Committee for Response Against the Ebola Virus, CDC Guinea Response Team et al. Update: Ebola virus disease outbreak--West Africa, October 2014. MMWR Morb Mortal Wkly Rep 2014; 63:978–81. - PMC - PubMed
    1. Kilmarx PH, Clarke KR, Dietz PM, et al. . Ebola virus disease in health care workers—Sierra Leone, 2014. MMWR Morb Mortal Wkly Rep 2014; 63:1167–71. - PMC - PubMed
    1. World Health Organization. Meeting Summary of the WHO Consultation on Potential Ebola Therapies and Vaccines. Geneva, Switzerland: World Health Organization; 2014.
    1. Geisbert TW, Feldmann H. Recombinant vesicular stomatitis virus-based vaccines against Ebola and Marburg virus infections. J Infect Dis 2011; 204(Suppl 3):S1075–81. - PMC - PubMed

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