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Review
. 2018 May 23;23(6):1241.
doi: 10.3390/molecules23061241.

Design and Efficacy of Nanogels Formulations for Intranasal Administration

Blessing A Aderibigbe  1 , Tobeka Naki  2
Affiliations
Review

Design and Efficacy of Nanogels Formulations for Intranasal Administration

Blessing A Aderibigbe et al. Molecules. .

Abstract

Nanogels are drug delivery systems that can bypass the blood-brain barrier and deliver drugs to the desired site when administered intranasally. They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer disease, migraine, schizophrenia and depression. nanogels have also been developed as vaccine carriers for the protection of bacterial infections such as influenza, meningitis, pneumonia and as veterinary vaccine carriers for the protection of animals from encephalomyelitis and mouth to foot disease. It has been developed as vaccine carriers for the prevention of lifestyle disease such as obesity. Intranasal administration of therapeutics using nanogels for the management of brain diseases revealed that the drug transportation was via the olfactory nerve pathway resulting in rapid drug delivery to the brain with excellent neuroprotective effect. The application of nanogels as vaccine carriers also induced significant responses associated with protective immunity against selected bacterial and viral infections. This review provides a detailed information on the enhanced therapeutic effects, mechanisms and biological efficacy of nanogels for intranasal administration.

Keywords: Alzheimer disease; HIV; depression; hypertension; influenza; nanogels; obesity; veterinary vaccine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Anatomy of the nose.
Figure 2
Figure 2
Pathways of nose-to-brain delivery.
Figure 3
Figure 3
Pathway of therapeutics to the brain.
Figure 4
Figure 4
Nanogel as vaccine carriers.
See this image and copyright information in PMC

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