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Editorial
. 2018 May 22;9(1):1939.
doi: 10.1038/s41467-018-04159-y.

Building better yeast

No authors listed
Editorial

Building better yeast

No authors listed. Nat Commun. .

Abstract

The Sc2.0 project has set out to synthesise the Saccharomyces cerevisiae genome, with each chromosome redesigned along agreed principles. In this collection of papers, the researchers involved show how SCRaMbLE—Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution—can be used to rapidly reorganise the genome.

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References

    1. Richardson SM, et al. Design of a synthetic yeast genome. Science. 2017;355:1040–1044. doi: 10.1126/science.aaf4557. - DOI - PubMed
    1. Dymond JS, et al. Synthetic chromosome arms function in yeast and generate phenotypic diversity by design. Nature. 2011;477:471–476. doi: 10.1038/nature10403. - DOI - PMC - PubMed
    1. Shen Y, et al. SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes. Genome Res. 2016;26:36–49. doi: 10.1101/gr.193433.115. - DOI - PMC - PubMed
    1. Blount BA, et al. Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome Nat. Commun. 10.1038/s41467-018-03143-w (2018). - PMC - PubMed
    1. Wu Y, et al. In vitro DNA SCRaMbLE Nat. Commun. 10.1038/s41467-018-03743-6 (2018). - PMC - PubMed

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