Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2018 Nov;28(11):4725-4734.
doi: 10.1007/s00330-018-5465-4. Epub 2018 May 22.

Pre-operative MRI staging of endometrial cancer in a multicentre cancer network: can we match single centre study results?

N D Soneji  1   2 , N Bharwani  3 , A Ferri  3   4 , V Stewart  3 , A Rockall  3   5
Affiliations
Multicenter Study

Pre-operative MRI staging of endometrial cancer in a multicentre cancer network: can we match single centre study results?

N D Soneji et al. Eur Radiol. 2018 Nov.

Abstract

Objectives: To evaluate the staging accuracy of magnetic resonance imaging (MRI) for endometrial cancer in daily practice over a 3-year period at a tertiary referral centre receiving scans from a large number of hospitals with varying protocols. To compare these daily practice results to published data from single-centre studies.

Methods: After ethical approval, MRI staging records for 270 studies from nine network and three centre hospitals were retrospectively collected and compared with final operative histopathology. The International Federation of Gynaecology and Obstetrics (FIGO) stage, depth of invasion assessment and cervical stromal invasion were analysed and reasons for discrepancies reviewed.

Results: MRI-based complete FIGO stage was fully concordant with histopathology in 65.6%. MRI accuracy for depth of myometrial invasion and cervical stromal invasion was 73.3% and 89.3% respectively. Our results did not match the high accuracy previously reported in studies based on single centres.

Conclusions: Published MRI staging accuracy from small single-centre studies were not replicated in a tertiary referral centre receiving scans with heterogeneous protocols over a 3-year period. These results highlight the challenges faced in daily practice and may reflect achievable and realistic MRI staging accuracies in large rapid throughput referral networks. Adherence to standardised high-quality protocols may help to improve future results.

Key points: • Three-year MRI-staging accuracy for endometrial cancer in a multicentre cancer network • Daily practice MRI-staging accuracy did not meet results of single-centre studies • Large scale cancer network MRI-staging accuracies should be further evaluated • Treatment recommendations should be based on achievable MRI-staging accuracies.

Keywords: Cancer staging; Data accuracy; Endometrial cancer; Magnetic resonance imaging (MRI); Tertiary referral centre.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. AJR Am J Roentgenol. 2007 Jun;188(6):1577-87 - PubMed
    1. Cancer Imaging. 2014 Nov 12;14:32 - PubMed
    1. Int J Gynecol Cancer. 2016 Jan;26(1):2-30 - PubMed
    1. Radiology. 2004 May;231(2):372-8 - PubMed
    1. Eur Radiol. 2011 May;21(5):1102-10 - PubMed

Publication types

LinkOut - more resources