[EFFICACY OF ANTIARRHYTHMIC AGENTS UNDER CONDITIONS OF STIMULATION OF THE SYMPATHETIC NERVOUS SYSTEM]

Abstract

The problem of weakening of the action of antiarrhythmic drugs under conditions of activation of the sympathetic nervous system draws increasing attention of researchers. These conditions are frequently encountered in clinical practice in cases of ischemia, myocardial infarction, and in patients with sustained ventricular arrhythmia. In addition, sympathetic, hyperactivity is a characteristic feature of serious cardiovascular diseases including heart failure. The beta-adrenergic stimulation can significantly modulate the electrophysiological action of antiarrhythmic drugs. There are significant differences in the ability of antiarrhythmic drugs to retain efficacy on the background of sympathetic stimulation. Additional administration of beta-blockers to patients with ventricular tachycardia, cardiac insufficiency, cardiomyopathy and patients after myocardial infarction is highly effective and is worth of addition al investigation. The search for drugs whose effect is not affected by sympathetic stimulation is still topical.