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Review
. 2018;18(18):1536-1547.
doi: 10.2174/1389557518666180524112050.

1,2,4-Oxadiazole as a Privileged Scaffold for Anti-inflammatory and Analgesic Activities: A Review

Affiliations
Review

1,2,4-Oxadiazole as a Privileged Scaffold for Anti-inflammatory and Analgesic Activities: A Review

Gita Chawla. Mini Rev Med Chem. 2018.

Abstract

1,2,4-Oxadiazole is one of the important heterocycles used by medicinal chemists in designing a new therapeutic molecule. The compounds containing this nucleus are reported to have a wide range of pharmaceutical and biological applications including anti-inflammatory and analgesic activities. The fused and pendent 1,2,4-oxadiazole moiety has been traced in a number of well established, commercially available drugs. This review article provides an up to date information about techniques adopted for the synthesis of 1,2,4-oxadiazoles, and their therapeutic importance as anti-inflammatory and analgesic agents.

Keywords: 1,2,4-Oxadiazole; COX; NSAIDs; analgesic; anti-inflammatory..

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