. 2018 Sep;14(9):1126-1136.

doi: 10.1016/j.jalz.2018.04.004. Epub 2018 May 21.

Effect of Alzheimer's disease risk and protective factors on cognitive trajectories in subjective memory complainers: An INSIGHT-preAD study

Stefan J Teipel^{1

2}, Enrica Cavedo^{3

4

5

6

7}, Simone Lista^{3

4

5

6}, Marie-Odile Habert^{8

9}, Marie-Claude Potier¹⁰, Michel J Grothe^{1

2}, Stephane Epelbaum⁴, Luisa Sambati⁴, Geoffroy Gagliardi⁴, Nicola Toschi^{11

12

13}, Michael D Greicius¹⁴, Bruno Dubois⁴, Harald Hampel^{3

4

5

6}; INSIGHT-preAD study group; Alzheimer Precision Medicine Initiative (APMI)

Collaborators, Affiliations

Collaborators

C Audrain, A Auffret, H Bakardjian, F Baldacci, B Batrancourt, I Benakki, H Benali, H Bertin, A Bertrand, L Boukadida, F Cacciamani, V Causse, E Cavedo, S Cherif Touil, P A Chiesa, O Colliot, G Dalla Barba, M Depaulis, A Dos Santos, B Dubois, M Dubois, S Epelbaum, B Fontaine, H Francisque, G Gagliardi, A Genin, R Genthon, P Glasman, F Gombert, M O Habert, H Hampel, H Hewa, M Houot, N Jungalee, A Kas, M Kilani, V La Corte, F Le Roy, S Lehericy, C Letondor, M Levy, S Lista, M Lowrey, J Ly, O Makiese, I Masetti, A Mendes, C Metzinger, A Michon, F Mochel, R Nait Arab, F Nyasse, C Perrin, F Poirier, C Poisson, M C Potier, S Ratovohery, M Revillon, K Rojkova, K Santos-Andrade, R Schindler, M C Servera, L Seux, V Simon, D Skovronsky, M Thiebaut, O Uspenskaya, M Vlaincu, Lisi Flores Aguilar, Claudio Babiloni, Filippo Baldacci, Norbert Benda, Keith L Black, Arun L W Bokde, Ubaldo Bonuccelli, Karl Broich, René S Bun, Francesco Cacciola, Juan Castrillo, Enrica Cavedo, Roberto Ceravolo, Patrizia A Chiesa, Olivier Colliot, Cristina-Maria Coman, Jean-Christophe Corvol, Augusto Claudio Cuello, Jeffrey L Cummings, Herman Depypere, Bruno Dubois, Andrea Duggento, Stanley Durrleman, Valentina Escott-Price, Howard Federoff, Maria Teresa Ferretti, Massimo Fiandaca, Richard A Frank, Francesco Garaci, Remy Genthon, Nathalie George, Filippo S Giorgi, Manuela Graziani, Marion Haberkamp, Marie-Odile Habert, Harald Hampel, Karl Herholz, Eric Karran, Seung H Kim, Yosef Koronyo, Maya Koronyo-Hamaoui, Foudil Lamari, Todd Langevin, Stéphane Lehéricy, Simone Lista, Jean Lorenceau, Mark Mapstone, Christian Neri, Robert Nisticò, Francis Nyasse-Messene, Sid E O'Bryant, George Perry, Craig Ritchie, Katrine Rojkova, Simone Rossi, Amira Saidi, Emiliano Santarnecchi, Lon S Schneider, Olaf Sporns, Nicola Toschi, Steven R Verdooner, Andrea Vergallo, Nicolas Villain, Lindsay A Welikovitch, Janet Woodcock, Erfan Younesi

Affiliations

¹ German Center for Neurodegenerative Diseases (DZNE)-Rostock/Greifswald, Rostock, Germany.
² Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany.
³ AXA Research Fund & Sorbonne Université Chair, Paris, France.
⁴ Sorbonne Université, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France.
⁵ Institut du Cerveau et de la Moelle Épiniére (ICM), INSERM U 1127, CNRS UMR 7225, Paris, France.
⁶ Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
⁷ IRCCS Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy.
⁸ Département de Médecine Nucléaire, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
⁹ Laboratoire d'Imagerie Biomédicale, Sorbonne Universités, UPMC Univ Paris 06, Inserm U 1146, CNRS UMR 7371, Paris, France.
¹⁰ ICM Institut du Cerveau et de la Moelle épinière, CNRS UMR7225, INSERM U1127, UPMC, Hôpital de la Pitié-Salpêtrière, Paris, France.
¹¹ Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
¹² Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA.
¹³ Harvard Medical School, Boston, MA, USA.
¹⁴ Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

PMID: 29792873
DOI: 10.1016/j.jalz.2018.04.004

Effect of Alzheimer's disease risk and protective factors on cognitive trajectories in subjective memory complainers: An INSIGHT-preAD study

Stefan J Teipel et al. Alzheimers Dement. 2018 Sep.

. 2018 Sep;14(9):1126-1136.

doi: 10.1016/j.jalz.2018.04.004. Epub 2018 May 21.

Authors

Collaborators

C Audrain, A Auffret, H Bakardjian, F Baldacci, B Batrancourt, I Benakki, H Benali, H Bertin, A Bertrand, L Boukadida, F Cacciamani, V Causse, E Cavedo, S Cherif Touil, P A Chiesa, O Colliot, G Dalla Barba, M Depaulis, A Dos Santos, B Dubois, M Dubois, S Epelbaum, B Fontaine, H Francisque, G Gagliardi, A Genin, R Genthon, P Glasman, F Gombert, M O Habert, H Hampel, H Hewa, M Houot, N Jungalee, A Kas, M Kilani, V La Corte, F Le Roy, S Lehericy, C Letondor, M Levy, S Lista, M Lowrey, J Ly, O Makiese, I Masetti, A Mendes, C Metzinger, A Michon, F Mochel, R Nait Arab, F Nyasse, C Perrin, F Poirier, C Poisson, M C Potier, S Ratovohery, M Revillon, K Rojkova, K Santos-Andrade, R Schindler, M C Servera, L Seux, V Simon, D Skovronsky, M Thiebaut, O Uspenskaya, M Vlaincu, Lisi Flores Aguilar, Claudio Babiloni, Filippo Baldacci, Norbert Benda, Keith L Black, Arun L W Bokde, Ubaldo Bonuccelli, Karl Broich, René S Bun, Francesco Cacciola, Juan Castrillo, Enrica Cavedo, Roberto Ceravolo, Patrizia A Chiesa, Olivier Colliot, Cristina-Maria Coman, Jean-Christophe Corvol, Augusto Claudio Cuello, Jeffrey L Cummings, Herman Depypere, Bruno Dubois, Andrea Duggento, Stanley Durrleman, Valentina Escott-Price, Howard Federoff, Maria Teresa Ferretti, Massimo Fiandaca, Richard A Frank, Francesco Garaci, Remy Genthon, Nathalie George, Filippo S Giorgi, Manuela Graziani, Marion Haberkamp, Marie-Odile Habert, Harald Hampel, Karl Herholz, Eric Karran, Seung H Kim, Yosef Koronyo, Maya Koronyo-Hamaoui, Foudil Lamari, Todd Langevin, Stéphane Lehéricy, Simone Lista, Jean Lorenceau, Mark Mapstone, Christian Neri, Robert Nisticò, Francis Nyasse-Messene, Sid E O'Bryant, George Perry, Craig Ritchie, Katrine Rojkova, Simone Rossi, Amira Saidi, Emiliano Santarnecchi, Lon S Schneider, Olaf Sporns, Nicola Toschi, Steven R Verdooner, Andrea Vergallo, Nicolas Villain, Lindsay A Welikovitch, Janet Woodcock, Erfan Younesi

Affiliations

¹ German Center for Neurodegenerative Diseases (DZNE)-Rostock/Greifswald, Rostock, Germany.
² Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany.
³ AXA Research Fund & Sorbonne Université Chair, Paris, France.
⁴ Sorbonne Université, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France.
⁵ Institut du Cerveau et de la Moelle Épiniére (ICM), INSERM U 1127, CNRS UMR 7225, Paris, France.
⁶ Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
⁷ IRCCS Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy.
⁸ Département de Médecine Nucléaire, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
⁹ Laboratoire d'Imagerie Biomédicale, Sorbonne Universités, UPMC Univ Paris 06, Inserm U 1146, CNRS UMR 7371, Paris, France.
¹⁰ ICM Institut du Cerveau et de la Moelle épinière, CNRS UMR7225, INSERM U1127, UPMC, Hôpital de la Pitié-Salpêtrière, Paris, France.
¹¹ Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
¹² Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA.
¹³ Harvard Medical School, Boston, MA, USA.
¹⁴ Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

PMID: 29792873
DOI: 10.1016/j.jalz.2018.04.004

Abstract

Introduction: Cognitive change in people at risk of Alzheimer's disease (AD) such as subjective memory complainers is highly variable across individuals.

Methods: We used latent class growth modeling to identify distinct classes of nonlinear trajectories of cognitive change over 2 years follow-up from 265 subjective memory complainers individuals (age 70 years and older) of the INSIGHT-preAD cohort. We determined the effect of cortical amyloid load, hippocampus and basal forebrain volumes, and education on the cognitive trajectory classes.

Results: Latent class growth modeling identified distinct nonlinear cognitive trajectories. Education was associated with higher performing trajectories, whereas global amyloid load and basal forebrain atrophy were associated with lower performing trajectories.

Discussion: Distinct classes of cognitive trajectories were associated with risk and protective factors of AD. These associations support the notion that the identified cognitive trajectories reflect different risk for AD that may be useful for selecting high-risk individuals for intervention trials.

Keywords: Amyloid PET; Cholinergic basal forebrain; Hippocampus; Longitudinal cognitive change; Preclinical Alzheimer's disease.

PubMed Disclaimer

References

1. S Kielb, E Rogalski, S Weintraub, A Rademaker. Objective features of subjective cognitive decline in a United States national database. Alzheimers Dement. 13: 2017; 1337-1344
1. MM Machulda, VS Pankratz, TJ Christianson, RJ Ivnik, MM Mielke, RO Roberts, et al. Practice effects and longitudinal cognitive change in normal aging vs. incident mild cognitive impairment and dementia in the Mayo Clinic Study of Aging. Clin Neuropsychol. 27: 2013; 1247-1264
1. J Hassenstab, D Ruvolo, M Jasielec, C Xiong, E Grant, JC Morris. Absence of practice effects in preclinical Alzheimer's disease. Neuropsychology. 29: 2015; 940-948
1. JE Baker, YY Lim, RH Pietrzak, J Hassenstab, PJ Snyder, CL Masters, et al. Cognitive impairment and decline in cognitively normal older adults with high amyloid-beta: A meta-analysis. Alzheimers Dement (Amst). 6: 2017; 108-121
1. SE Schindler, MS Jasielec, H Weng, JJ Hassenstab, E Grober, LM McCue, et al. Neuropsychological measures that detect early impairment and decline in preclinical Alzheimer disease. Neurobiol Aging. 56: 2017; 25-32

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

Grants and funding

P50 AG047366/AG/NIA NIH HHS/United States

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Wiley
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Effect of Alzheimer's disease risk and protective factors on cognitive trajectories in subjective memory complainers: An INSIGHT-preAD study

Collaborators

Affiliations

Effect of Alzheimer's disease risk and protective factors on cognitive trajectories in subjective memory complainers: An INSIGHT-preAD study

Authors

Collaborators

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical