Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Aug;69(2):275-277.
doi: 10.1016/j.jhep.2018.05.012. Epub 2018 May 21.

Exploring new treatment paradigms for alcoholic hepatitis by extrapolating from NASH and cholestasis

Thoetchai Bee Peeraphatdit  1 , Douglas A Simonetto  1 , Vijay H Shah  2
Affiliations
Editorial

Exploring new treatment paradigms for alcoholic hepatitis by extrapolating from NASH and cholestasis

Thoetchai Bee Peeraphatdit et al. J Hepatol. 2018 Aug.
No abstract available

PubMed Disclaimer

Figures

Figure
Figure
Bile-acid and non-bile acid treatment targets of nonalcoholic hepatitis and cholestasis that can be opportunities in alcoholic hepatitis. Abbreviations: ASK1 = apoptosis signal-regulating kinase 1, C4 = 7α-Hydroxy-4-cholesten-3-one, CCR2/5 = C-C chemokine receptor type 2/5, FGF = fibroblast growth factor, FXR = farnesnoid X receptor, PPAR = peroxisome proliferator-activated receptor ©Mayo Foundation for Medical Education and Research. All rights reserved.
See this image and copyright information in PMC

Comment on

  • Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis.
    Brandl K, Hartmann P, Jih LJ, Pizzo DP, Argemi J, Ventura-Cots M, Coulter S, Liddle C, Ling L, Rossi SJ, DePaoli AM, Loomba R, Mehal WZ, Fouts DE, Lucey MR, Bosques-Padilla F, Mathurin P, Louvet A, Garcia-Tsao G, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross D, Stärkel P, Ho SB, Bataller R, Schnabl B. Brandl K, et al. J Hepatol. 2018 Aug;69(2):396-405. doi: 10.1016/j.jhep.2018.03.031. Epub 2018 Apr 12. J Hepatol. 2018. PMID: 29654817 Free PMC article.

References

    1. Maddrey WC, et al. , Corticosteroid therapy of alcoholic hepatitis. Gastroenterology, 1978. 75(2): p. 193–9. - PubMed
    1. Thursz MR, et al. , Prednisolone or Pentoxifylline for Alcoholic Hepatitis. New England Journal of Medicine, 2015. 372(17): p. 1619–1628. - PubMed
    1. Singal AK, et al. , Alcoholic Hepatitis: Current Challenges and Future Directions. Clinical Gastroenterology and Hepatology, 2014. 12(4): p. 555–564. - PMC - PubMed
    1. Petrasek J, et al. , IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. The Journal of Clinical Investigation, 2012. 122(10): p. 3476–3489. - PMC - PubMed
    1. Malhi H and Camilleri M, Modulating bile acid pathways and TGR5 receptors for treating liver and GI diseases. Curr Opin Pharmacol, 2017. 37: p. 80–86. - PMC - PubMed