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. 2018 May 24;13(5):e0196721.
doi: 10.1371/journal.pone.0196721. eCollection 2018.

Neonatal and maternal serum creatinine levels during the early postnatal period in preterm and term infants

Hayato Go  1 , Nobuo Momoi  1 , Nozomi Kashiwabara  1 , Kentaro Haneda  1 , Mina Chishiki  1 , Takashi Imamura  1 , Maki Sato  1 , Aya Goto  2 , Yukihiko Kawasaki  1 , Mitsuaki Hosoya  1
Affiliations

Neonatal and maternal serum creatinine levels during the early postnatal period in preterm and term infants

Hayato Go et al. PLoS One. .

Abstract

We investigated the relationship of neonatal and maternal serum creatinine (nSCr and mSCr, respectively) with various maternal/infant characteristics at different gestational ages (GA). We reviewed medical records of neonates admitted to NICU. We collected data on birth weight, GA, Apgar scores, medications, etc. Spearman's test was used to analyze the correlation between serum creatinine and continuous variables, and the Mann-Whitney U and Kruskal-Wallis tests for continuous variables between groups. The changes in nSCr, mSCr, and nSCr/mSCr ratio because of gestational age and the points in gestational changes in trends were estimated using joinpoint trend analysis. From 614 neonate and mother pairs, we found that nSCr was significantly correlated with GA. However, mSCr at >28 wks decreased with GA. The nSCr/mSCr ratio was correlated with GA. In infants born <29 weeks, pregnancy-induced hypertension (PIH) (p = 0.000, β = 0.20) and mSCr (p = 0.000, β = 0.73) were significantly associated with nSCr. In term infants, maternal magnesium administration (p = 0.000, β = 0.25), respiratory distress syndrome (p = 0.013, β = 0.16), PIH (p = 0.005, β = 0.19), and mSCr (p = 0.000, β = 0.33) were significantly associated with nSCr. nSCr reflected mSCr at all gestational ages. The correlation between nSCr and mSCr in preterm infants (p = 0.000, β = 0.74) was stronger than in term infants (p = 0.000, β = 0.34).

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flowchart of subjects in this study.
Fig 2
Fig 2. Correlation between nSCr, mSCr and GA.
Joinpoint analysis using mean nSCr (A), mSCr (B), and ratio of nSCr/mSCr (C) from 22–41 weeks’ gestational age. Significant correlation between the values of GA, mSCr, and nSCr were analyzed using Spearman’s rank correlation(r) (A, C).
Fig 3
Fig 3. Creatinine levels during early postnatal period.
A. nSCr of preterm infants born at <29 weeks’ gestational age from birth until four weeks of life. B. Serum and plasma creatinine levels in three groups of preterm infants born at gestationsal age of <29 weeks’ at one month are presented as box (interquartile range) and whisker (5%–95% range) plots. Creatinine at day 7 was plasma creatinine. †P<0.05.
See this image and copyright information in PMC

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