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. 2018 Apr 17;9(5):408-410.
doi: 10.1021/acsmedchemlett.8b00128. eCollection 2018 May 10.

What Do You Get from DNA-Encoded Libraries?

Alexander L Satz  1
Affiliations

What Do You Get from DNA-Encoded Libraries?

Alexander L Satz. ACS Med Chem Lett. .

Abstract

Use of DNA-encoded libraries (DELs) in the pharmaceutical industry has rapidly increased. We discuss what to expect when you run a DEL screen and contemplate guidelines for library design. Additionally, we consider some visionary work and extrapolate to the future.

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Conflict of interest statement

The author declares no competing financial interest.

Figures

Figure 1
Figure 1
Molecules in the clinic are similar to their original DNA-encoded library (DEL) hits.
Figure 2
Figure 2
Molecular weights of all DEL-derived Roche hits.
See this image and copyright information in PMC

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