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Review
. 2018 Aug 1;27(R2):R99-R107.
doi: 10.1093/hmg/ddy187.

Use and application of 3D-organoid technology

Benedetta Artegiani  1   2 , Hans Clevers  1   2
Affiliations
Review

Use and application of 3D-organoid technology

Benedetta Artegiani et al. Hum Mol Genet. .

Abstract

The capacity of the 3D-organoid cultures to resemble a near-physiological tissue organization and to mimic - to a certain degree - organ functionality, make organoids an excellent model for applications spanning from basic developmental/stem cell research to personalized medicine. Here, we review key findings achieved through organoid technology, and we discuss applications such as disease - and tumour modelling, correction of genetic mutations and understanding gene - and cell functions. Finally, we discuss future developments in the field.

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