[Clinical significance and research progress of pepsin in laryngopharygeal reflux and laryngeal carcinoma]

Abstract

Laryngeal carcinoma is a common malignancy, and the incidence of this disease is on the rise. In recent years, more and more studies of the etiology and risk factors have confirmed the correlation between laryngopharygeal reflux and the incidence of laryngeal carcinoma. Laryngopharygeal reflux is defined as reflux of the stomach contents above the upper esophageal sphincter. Stimulation and injury of acid to the esophagus and throat mucosa have now been studied more thoroughly, and pepsin plays an increasingly important role in laryngopharygeal reflux disease. The incidence of laryngopharygeal reflux in patients with laryngeal carcinoma reported in the literature was 54.0%-88.7%, mainly because of mucosal injury due to the combined effect of gastric acid and pepsin. This article reviews the significance of pepsin in laryngopharygeal reflux, its mechanism of action and related clinical detection methods.

Keywords: laryngeal neoplasms; laryngopharygeal reflux; pepsin.