[A review on group 2 innate lymphoid cells and miR-155 in allergic rhinitis]

Abstract

Allergic rhinitis (AR) is the Th2 inflammatory response that atopic individuals exposure to allergens, mediators released by IgE-mediated, and a variety of immunocompetent cells and cytokines involved .Group 2 innate lymphoid cells (ILC2) are a novel population of native lymphocyte, can secrete large amounts of Th2 cytokines to promote the development of allergic diseases after being activated. MiR-155 plays a vital role in the development of the immune system, the differentiation of immune cells, and the maintenance of immune function.Nasal mucosas from the patients with allergic rhinitis show enrichment for ILC2 and miR-155. Highly expressed miR-155 may enhance the level of IL-4 by promoting ILC2 expression, thereby promoting Th2 inflammatory response.This review focuses on the function and meaning of ILC2 and miR-155 in patients with Allergic rhinitis.

Keywords: MiR-155; group 2 innate lymphoid cells; head impulse test; rhinitis, allergic.