[Effects of nasal steroids on pulmonary function in patients with allergic rhinitis]

Abstract

Objective:The aim of this study was to observe the changes of pulmonary function in patients with allergic rhinitis and the effect of nasal glucocorticoid on pulmonary function.Method:Ninety patients with Moderate and severe AR and 50 healthy control subjects were recruited.All participates accepted a pulmonary function test and make a statistical analysis.90 patients of AR were divided into two groups:A group(50) and B group(40).A group treated with nasal budesonide and loratadine,while B group treated with nasal normal saline and loratadine.After 3 months,all patients reviewed the lung function.Result:Comparing with control,FEV1.0/FVC,MMEF,FEF50% and FEF75% reduced significantly in AR group(P<0.01),after 3 months,the treatment of A group compared before:FEV1.0/FVC(P<0.05),MMEF,FEF50% and FEF75%(P<0.01) had statistical significance.Compared B group after the treatment:FEF75% (P<0.05) was significant.After the treatment of group A compared with normal group:there was no significance.Conclusion:The reduced pulmonary function of allergic rhinitis paitents is mainly due to the small airway dysfunction.Budesonide is superior to loratadine to improve the pulmonary function.

Keywords: budesonide; pulmonary function; rhinitis,allergic; small airway.