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Editorial
. 2018 May 25;122(11):1485-1487.
doi: 10.1161/CIRCRESAHA.118.313109.

Cross Talk Between S-Nitrosylation and Phosphorylation Involving Kinases and Nitrosylases

Hua-Lin Zhou  1 , Colin T Stomberski  1   2 , Jonathan S Stamler  3   2   4
Affiliations
Editorial

Cross Talk Between S-Nitrosylation and Phosphorylation Involving Kinases and Nitrosylases

Hua-Lin Zhou et al. Circ Res. .
No abstract available

Keywords: Editorials; kinase; nitric oxide; phosphorylation.

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Figures

Figure
Figure
(a) S-nitrosylation directly inhibits kinase activity. SNO: S-nitrosylation; P: phosphorylation. (b) S-nitrosylation disrupts kinase-substrate interaction. (c) S-nitrosylation changes GSK3β localization and determines substrate specificity. (d) Phosphorylation and S-nitrosylation alternatively modify β-arrestin1 and β-arrestin2 to regulate GPCR internalization. (e) S-nitrosylation converts CDK5 from kinase to nitrosylase.
See this image and copyright information in PMC

Comment on

References

    1. Wang S, Venkatraman V, Crowgey EL, Liu T, Fu Z, Holewinski R, Ranek M, Kass DA, O’Rourke B, EyK JEV. Protein S-Nitrosylation Controls Glycogen Synthase Kinase 3β Function Independent of its Phosphorylation State. Circ Res. 2018 In press. - PMC - PubMed
    1. Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman HA, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. 2007;129:511–22. - PubMed
    1. Huang ZM, Gao E, Fonseca FV, Hayashi H, Shang X, Hoffman NE, Chuprun JK, Tian X, Tilley DG, Madesh M, Lefer DJ, Stamler JS, Koch WJ. Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury. Sci Signal. 2013;6:ra95. - PMC - PubMed
    1. Choi H, Tostes RC, Webb RC. S-nitrosylation Inhibits protein kinase C-mediated contraction in mouse aorta. J Cardiovasc Pharmacol. 2011;57:65–71. - PMC - PubMed
    1. Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, Kaneki M. S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance. J Biol Chem. 2005;280:7511–8. - PubMed

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