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Comment
. 2018 Aug 15;24(16):3790-3791.
doi: 10.1158/1078-0432.CCR-18-0855. Epub 2018 May 24.

Targeted Therapies for Brain Tumors: Will They Ever Deliver?

Michael A Vogelbaum  1
Affiliations
Comment

Targeted Therapies for Brain Tumors: Will They Ever Deliver?

Michael A Vogelbaum. Clin Cancer Res. .

Abstract

The strategy of using biologically targeted therapeutics for cancer has yet to translate into effective treatment of gliomas. The neuro-oncology community is beginning to recognize that phase 0 studies should be performed to account for the impact of the blood-brain barrier on the ability of a therapeutic to reach its target(s). Clin Cancer Res; 24(16); 3790-1. ©2018 AACRSee related article by Sanai et al., p. 3820.

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  • Phase 0 Trial of AZD1775 in First-Recurrence Glioblastoma Patients.
    Sanai N, Li J, Boerner J, Stark K, Wu J, Kim S, Derogatis A, Mehta S, Dhruv HD, Heilbrun LK, Berens ME, LoRusso PM. Sanai N, et al. Clin Cancer Res. 2018 Aug 15;24(16):3820-3828. doi: 10.1158/1078-0432.CCR-17-3348. Epub 2018 May 24. Clin Cancer Res. 2018. PMID: 29798906 Free PMC article. Clinical Trial.

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