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. 2018 Jul 1;75(7):749-751.
doi: 10.1001/jamapsychiatry.2018.0844.

Stability of the Brain Functional Connectome Fingerprint in Individuals With Schizophrenia

Tobias Kaufmann  1 , Dag Alnæs  1 , Christine L Brandt  1 , Francesco Bettella  1 , Srdjan Djurovic  2 , Ole A Andreassen  1 , Lars T Westlye  3
Affiliations

Stability of the Brain Functional Connectome Fingerprint in Individuals With Schizophrenia

Tobias Kaufmann et al. JAMA Psychiatry. .

Abstract

This study combines data from 3 existing functional magnetic resonance imaging data sets of people with schizophrenia spectrum disorders and healthy controls to assess the association of schizophrenia spectrum disorders with connectome stability.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Andreassen reports receiving a speaker’s honorarium from Lundbeck and Sunovion, unrelated to this work. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. Overview of Analysis
FEAT indicates functional magnetic resonance imaging (fMRI) expert analysis tool; FIX, fMRI of the brain (FMRIB) independent component analysis–based Xnoiseifier; FSL, FMRIB software library; MCFLIRT, Motion Correction of FMRIB’s Linear Image Registration Tool; MNI, Montreal Neurological Institute; NMorphCH, Neuromorphometry by Computer Algorithm Chicago; TOP, Thematically Organized Psychosis study. ds000115 is a data set accession number.
Figure 2.
Figure 2.. Connectome Stability in Schizophrenia Spectrum Disorders
A, C, and D, Connectome stability data are residualized for age, age squared, sex, motion, temporal signal-to-noise ratio, and scanning site; B, Connectome stability data are residualized for sex, motion, temporal signal-to-noise ratio, and scanning site. A, Statistically significant differences were found in the full brain and several subnetworks. B, Age trajectories in data on 369 participants suggest a decrease in connectome stability with adult age. C, Association of connectome stability in the motor network of 165 participants with polygenic risk for schizophrenia. D, Association of connectome stability in the visual association network of 365 participants with 2-back task performance.
See this image and copyright information in PMC

References

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