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. 2018 Jul 1;4(7):996-998.
doi: 10.1001/jamaoncol.2018.0818.

Assessment of Electronic Alert to Reduce Overuse of Granulocyte Colony-Stimulating Factor in Patients Hospitalized for Febrile Neutropenia

Melissa K Accordino  1   2 , Jason D Wright  2   3 , Sowmya Vasan  4 , Donna L Buono  4 , Jim C Hu  5 , Alfred I Neugut  1   2   4 , Dawn L Hershman  1   2   4
Affiliations

Assessment of Electronic Alert to Reduce Overuse of Granulocyte Colony-Stimulating Factor in Patients Hospitalized for Febrile Neutropenia

Melissa K Accordino et al. JAMA Oncol. .

Erratum in

  • Corrected Disclosures Statement.
    [No authors listed] [No authors listed] JAMA Oncol. 2019 Sep 1;5(9):1372. doi: 10.1001/jamaoncol.2019.3356. JAMA Oncol. 2019. PMID: 31369036 Free PMC article. No abstract available.

Abstract

This study evaluates the efficacy of an alert in the electronic health record to reduce overuse of granulocyte colony-stimulating factor in older patients hospitalized with febrile neutropenia.

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Conflict of interest statement

Funding/Support: Dr Accordino reported receiving a Young Investigator Award and Career Development Award from the American Society of Clinical Oncology/Breast Cancer Research Foundation and a Dr Charles A. Coltman Jr Fellowship from the Hope Foundation. Dr Hershman reported receiving grants from The American Society of Clinical Oncology and the Breast Cancer Research Foundation. No other disclosures were reported.

Figures

Figure.
Figure.. Use of Granulocyte Colony-Stimulating Factor (G-CSF) in Patients Hospitalized With Febrile Neutropenia
Among all patients, use of G-CSF did not change after the implementation of an alert in the electronic health record. ICU indicates intensive care unit.
See this image and copyright information in PMC

References

    1. Smith TJ, Bohlke K, Lyman GH, et al. ; American Society of Clinical Oncology . Recommendations for the use of WBC growth factors: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2015;33(28):3199-3212. - PubMed
    1. Clark OA, Lyman GH, Castro AA, Clark LG, Djulbegovic B. Colony-stimulating factors for chemotherapy-induced febrile neutropenia: a meta-analysis of randomized controlled trials. J Clin Oncol. 2005;23(18):4198-4214. - PubMed
    1. Wright JD, Neugut AI, Ananth CV, et al. . Deviations from guideline-based therapy for febrile neutropenia in cancer patients and their effect on outcomes. JAMA Intern Med. 2013;173(7):559-568. - PMC - PubMed
    1. van der Sijs H, Aarts J, Vulto A, Berg M. Overriding of drug safety alerts in computerized physician order entry. J Am Med Inform Assoc. 2006;13(2):138-147. - PMC - PubMed
    1. Bansal A, Sullivan SD, Hershman DL, et al. . A stakeholder-informed randomized, controlled comparative effectiveness study of an order prescribing intervention to improve colony stimulating factor use for cancer patients receiving myelosuppressive chemotherapy: the TrACER study. J Comp Eff Res. 2017;6(5):461-470. - PMC - PubMed

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