The association between interleukin polymorphism and recurrent aphthous stomatitis: A meta-analysis

Abstract

Objective: To assess the association between interleukin gene polymorphism and recurrent aphthous stomatitis (RAS).

Designs: Two electronic databases, PubMed and Embase, were utilized to assemble potentially relevant studies meeting the inclusion criteria. A meta-analysis was conducted using Revman 5.3 software (London, UK), and the pooled odds ratio (OR) and 95% confidence interval (CI) were then used to evaluate the strength of the relationship between the gene polymorphisms of IL-1beta(-511C/T), IL-1beta(+3954C/T), IL-6(-174G/C) and IL-10(-1082G/A) and the risk of RAS.

Results: Ten studies were included in the final meta-analysis, with 884 cases and 1104 controls participating. The results demonstrated that the polymorphism of IL-1beta(-511C/T) significantly increased the probability of the development of RAS in Europeans. (T vs. C: OR = 1.35, 95%CI = 1.09-1.67; CC vs. CT + TT: OR = 1.77, 95%CI = 1.24-2.53; CC vs. TT: OR = 1.86, 95%CI = 1.18-2.95). Furthermore, the C allele in IL-1beta(+3954C/T) was determined to be related to the risk of RAS in Americans (C vs. T: OR = 1.52, 95%CI = 1.07-2.17) and the presence of the C gene was considered a risk variant (CC + CT vs. TT: OR = 1.46, 95%CI = 1.01-2.11), but no relationship was found between the polymorphism of IL-10(-1082G/A) and the risk of RAS.

Conclusions: The meta-analysis suggested that the mutation of IL-1beta(-511C/T) in Europe and IL-1beta(+3954C/T) in America tend to increase the risk of RAS, but the polymorphism of IL-10(-1082G/A) appears to have no association with RAS risk in America. Further study is required to confirm the above conclusions.

Keywords: Gene polymorphism; Genetic susceptibility; ILs; Meta-analysis; Recurrent aphthous stomatitis.