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Review
. 2018 May 26;19(5):1161-1167.
doi: 10.22034/APJCP.2018.19.5.1161.

Oral Lichen Planus: an Overview of Potential Risk Factors, Biomarkers and Treatments

Tahereh Nosratzehi  1
Affiliations
Review

Oral Lichen Planus: an Overview of Potential Risk Factors, Biomarkers and Treatments

Tahereh Nosratzehi. Asian Pac J Cancer Prev. .

Abstract

Oral lichen planus (OLP) is an immune-related disorder with unknown exact etiology but established prevalence in females. There are six clinical forms of OLP, ranging from asymptomatic white keratotic lesions to painful erosions and ulcerations. The aim of the present report is to overview pathologic and therapeutic aspects. Peroxidation products, antioxidants, cortisol, and immunoglobulins are potential biomarkers to predict OLP occurrence. The risk of OLP development in patients with hepatitis B and C infection is 2-fold greater than in healthy individuals, while there is no significant relation with diabetes mellitus. Corticosteroids are common drugs to treat OLP and their combination with other agents can be most effective. Folic acid and variants of vitamin B are also potential treatments since they target hematological abnormalities.

Keywords: Lichen Planus; oral; diagnosis; hepatitis; therapeutics; vitamins.

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Figures

Figure 1
Figure 1
Risk of OLP Development in Hepatitis Patients are more than Healthy Individuals and Diabetic Patients.
See this image and copyright information in PMC

References

    1. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin:preclinical and clinical studies. Anticancer Res. 2003;23:363–98. - PubMed
    1. Ahmed I, Nasreen S, Jehangir U, et al. Frequency of oral lichen planus in patients with noninsulin dependent diabetes mellitus. J Pak Assoc Dermatol. 2012;22:30–4.
    1. Alavian SM, Jabbari H, Daryani NE. Hepatitis C virus:the rising concerns and growing hopes, report from the HCV symposium, fourth Tehran hepatitis congress, November 2011, Tehran, Iran. Hepat Mon. 2012;12:423.
    1. Allison P, Locker D, Feine JS. The role of diagnostic delays in the prognosis of oral cancer:a review of the literature. Oral Oncol. 1998;34:161–70. - PubMed
    1. Ansar A, Farshchian M, Ghasemzadeh SM. Comparison of the frequency of diabetes mellitus in the patientswith lichen planus and normal controls:A case-control study. J Cosmet Dermatol. 2011a;2:78–84.