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Review
. 2018 May 4;9(34):23824-23842.
doi: 10.18632/oncotarget.25323.

Oxidative stress in female cancers

Gloria M Calaf  1   2 , Ulises Urzua  3 , Lara Termini  4 , Francisco Aguayo  3   5
Affiliations
Review

Oxidative stress in female cancers

Gloria M Calaf et al. Oncotarget. .

Abstract

Breast, cervical and ovarian cancers are highly prevalent in women worldwide. Environmental, hormonal and viral-related factors are especially relevant in the development of these tumors. These factors are strongly related to oxidative stress (OS) through the generation of reactive oxygen species (ROS). The OS is caused by an imbalance in the redox status of the organism and is literally defined as "an imbalance between ROS generation and its detoxification by biological system leading to impairment of damage repair by cell/tissue". The multistep progression of cancer suggests that OS is involved in cancer initiation, promotion and progression. In this review, we described the role of OS and the interplay with environmental, host and viral factors related to breast, cervical and ovarian cancers initiation, promotion and progression. In addition, the role of the natural antioxidant compound curcumin and other compounds for breast, cervical and ovarian cancers prevention/treatment is discussed.

Keywords: breast; cervical; curcumin; ovarian cancer; oxidative stress.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest

Figures

Figure 1
Figure 1. Systematic literature analysis of genes associated to oxidative stress in female cancers
PubMed was used via the text-mining tool SciMiner (http://hurlab.med.und.edu/SciMiner/, accessed August 1st, 2017) with the keywords “breast cancer” and “ROS”, “cervical cancer” and “ROS”, and “ovarian cancer” and “ROS” in separate queries. Using the default settings of SciMiner, the output resulted in 984, 213 and 289 breast cancer (BC), cervical cancer (CC) and ovarian cancer (OC)-associated genes, respectively. The Venn diagram was obtained with VENNY 2.1 (Oliveros JC, 2007–2015. Venny. An interactive tool for comparing lists with Venn's diagrams. http://bioinfogp.cnb.csic.es/tools/venny/index.html). The resultant list of 113 genes overlapping the 3 queries was subjected to the gene ontology (GO) analysis described in Table 1.
See this image and copyright information in PMC

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