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Meta-Analysis
. 2018 May 28;17(1):126.
doi: 10.1186/s12944-018-0767-8.

Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis

Joseph Sam Kanu  1 , Shuang Qiu  1 , Yi Cheng  2 , Ri Li  1 , Changgui Kou  1 , Yulu Gu  1 , Ye Bai  1 , Jikang Shi  1 , Yong Li  1 , Yunkai Liu  2 , Yaqin Yu  1 , Yawen Liu  3
Affiliations
Meta-Analysis

Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis

Joseph Sam Kanu et al. Lipids Health Dis. .

Abstract

Background: Inconsistencies have existed in research findings on the association between cardiovascular disease (CVD) and single nucleotide polymorphisms (SNPs) of ADIPOQ, triggering this up-to-date meta-analysis.

Methods: We searched for relevant studies in PubMed, EMBASE, Cochrane Library, CNKI, CBM, VIP, and WanFang databases up to 1st July 2017. We included 19,106 cases and 31,629 controls from 65 published articles in this meta-analysis. STATA 12.0 software was used for all statistical analyses.

Results: Our results showed that rs266729 polymorphism was associated with the increased risk of CVD in dominant model or in heterozygote model; rs2241766 polymorphism was associated with the increased risk of CVD in the genetic models (allelic, dominant, recessive, heterozygote, and homozygote). In subgroup analysis, significant associations were found in different subgroups with the three SNPs. Meta-regression and subgroup analysis showed that heterogeneity might be explained by other confounding factors. Sensitivity analysis revealed that the results of our meta-analysis were stable and robust. In addition, the results of trial sequential analysis showed that evidences of our results are sufficient to reach concrete conclusions.

Conclusions: In conclusion, our meta-analysis found significant increased CVD risk is associated with rs266729 and rs2241766, but not associated with rs1501299.

Keywords: ADIPOQ; Association; Cardiovascular disease; Meta-analysis; Single nucleotide polymorphisms.

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Conflict of interest statement

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Not applicable.

Competing interests

The authors declared that they have no competing interest.

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Figures

Fig. 1
Fig. 1
Flow diagram showing details of results of databases searched exclusion and inclusion of studies/articles in the meta-analysis. CNKI: Chinese National Knowledge Infrastructure; CBM: Chinese BioMedical Literature on Disc
Fig. 2
Fig. 2
Forest plots of the association between rs266729 polymorphism and CVD risk. (a) dominant model; (b) heterozygote model
Fig. 3
Fig. 3
Forest plots of the association between rs2241766 polymorphism and CVD risk. (a) allelic model; (b) dominant model; (c) recessive model; (d) heterozygote model; (e) homozygote model
Fig. 4
Fig. 4
Sensitivity analyses of the association between rs266729 polymorphism and CVD risk. (a) allelic model; (b) dominant model; (c) recessive model; (d) heterozygote model; (e) homozygote model
Fig. 5
Fig. 5
Sensitivity analyses of the association between rs2241766 polymorphism and CVD risk. (a) allelic model; (b) dominant model; (c) recessive model; (d) heterozygote model; (e) homozygote model
Fig. 6
Fig. 6
Sensitivity analyses of the association between rs1501299 polymorphism and CVD risk. (a) allelic model; (b) dominant model; (c) recessive model; (d) heterozygote model; (e) homozygote model
Fig. 7
Fig. 7
Trial sequential analysis of the association between rs266729 and CVD risk. (a) allelic model; (b) dominant model; (c) recessive model; (d) heterozygote model; (e) homozygote model
Fig. 8
Fig. 8
Trial sequential analysis of the association between rs2241766 and CVD risk. (a) allelic model; (b) dominant model; (c) recessive model; (d) heterozygote model; (e) homozygote model
Fig. 9
Fig. 9
Trial sequential analysis of the association between rs1501299 and CVD risk. (a) allelic model; (b) dominant model; (c) recessive model; (d) heterozygote model; (e) homozygote model
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