Modeling cytokine release syndrome

Affiliations

¹ Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. crooney@bcm.edu.
² Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Comment

Cliona Rooney et al. Nat Med. 2018 Jun.

. 2018 Jun;24(6):705-706.

doi: 10.1038/s41591-018-0068-9.

¹ Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. crooney@bcm.edu.
² Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

No abstract available

Comment on

CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade.
Giavridis T, van der Stegen SJC, Eyquem J, Hamieh M, Piersigilli A, Sadelain M. Giavridis T, et al. Nat Med. 2018 Jun;24(6):731-738. doi: 10.1038/s41591-018-0041-7. Epub 2018 May 28. Nat Med. 2018. PMID: 29808005 Free PMC article.
Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells.
Norelli M, Camisa B, Barbiera G, Falcone L, Purevdorj A, Genua M, Sanvito F, Ponzoni M, Doglioni C, Cristofori P, Traversari C, Bordignon C, Ciceri F, Ostuni R, Bonini C, Casucci M, Bondanza A. Norelli M, et al. Nat Med. 2018 Jun;24(6):739-748. doi: 10.1038/s41591-018-0036-4. Epub 2018 May 28. Nat Med. 2018. PMID: 29808007