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. 2018 Jun 15;20(12):3460-3464.
doi: 10.1021/acs.orglett.8b01159. Epub 2018 May 29.

Multicomponent Synthesis of Tetrahydroisoquinolines

Linwei Zeng  1 , Bo Huang  1 , Yangyong Shen  1 , Sunliang Cui  1   2
Affiliations

Multicomponent Synthesis of Tetrahydroisoquinolines

Linwei Zeng et al. Org Lett. .

Abstract

A multicomponent synthesis of tetrahydroisoquinolines from carboxylic acids, alkynyl ethers, and dihydroisoquinolines is described. This process features readily available starting materials, simple experimental procedures for achievement of molecule complexity, and structural diversity. The preliminary control experiment and crossover reaction provide important insight into the reaction mechanism. The formed tetrahydroisoquinolines could be transformed to an array of compounds.

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