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Comment
. 2018 May 29:7:e37732.
doi: 10.7554/eLife.37732.

Coloring hidden viruses

Marina Lusic  1
Affiliations
Comment

Coloring hidden viruses

Marina Lusic. Elife. .

Abstract

An improved dual-color reporter reveals how the fate of latent HIV-1 depends on where it integrates in the human genome.

Keywords: HIV-1 latency; human; infectious disease; integration sites; latency reversal; latency reversing agents; microbiology; reservoirs; virus.

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Conflict of interest statement

ML No competing interests declared

Figures

Figure 1.
Figure 1.. Scanning electron micrograph of an HIV-infected T cell.
The human immunodeficiency virus (HIV; yellow) buds from the surface of a productively infected T cell (red).
See this image and copyright information in PMC

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References

    1. Barton K, Hiener B, Winckelmann A, Rasmussen TA, Shao W, Byth K, Lanfear R, Solomon A, McMahon J, Harrington S, Buzon M, Lichterfeld M, Denton PW, Olesen R, Østergaard L, Tolstrup M, Lewin SR, Søgaard OS, Palmer S. Broad activation of latent HIV-1 in vivo. Nature Communications. 2016;7:12731. doi: 10.1038/ncomms12731. - DOI - PMC - PubMed
    1. Battivelli E, Dahabieh MS, Abdel-Mohsen M, Svensson JP, Tojal Da Silva I, Cohn LB, Gramatica A, Deeks S, Greene WC, Pillai SK, Verdin E. Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells. eLife. 2018;7:e34655. doi: 10.7554/eLife.34655. - DOI - PMC - PubMed
    1. Calvanese V, Chavez L, Laurent T, Ding S, Verdin E. Dual-color HIV reporters trace a population of latently infected cells and enable their purification. Virology. 2013;446:283–292. doi: 10.1016/j.virol.2013.07.037. - DOI - PMC - PubMed
    1. Chavez L, Calvanese V, Verdin E. HIV latency is established directly and early in both resting and activated primary CD4 T cells. PLoS Pathogens. 2015;11:e1004955. doi: 10.1371/journal.ppat.1004955. - DOI - PMC - PubMed
    1. Chen HC, Martinez JP, Zorita E, Meyerhans A, Filion GJ. Position effects influence HIV latency reversal. Nature Structural & Molecular Biology. 2017;24:47–54. doi: 10.1038/nsmb.3328. - DOI - PubMed

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