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. 1985 Jan;53(1):89-93.
doi: 10.1128/JVI.53.1.89-93.1985.

Presence of markers for virulence in the unique short region or repeat region or both of pseudorabies hybrid viruses

A Berns, A van den Ouweland, W Quint, J van Oirschot, A Gielkens

Presence of markers for virulence in the unique short region or repeat region or both of pseudorabies hybrid viruses

A Berns et al. J Virol. 1985 Jan.

Abstract

The unique short region and part of the repeat region of virulent pseudorabies virus strain NIA-3 was replaced by the corresponding region of the avirulent NIA-4 strain by transfection with subgenomic DNA fragments. The resulting hybrid virus showed a reduced virulence in both mice and pigs. Therefore, important markers for virulence are located in the unique short or repeat region or both of pseudorabies virus. We provide evidence that the terminally located repeat is not required for the generation of progeny with intact pseudorabies virus genomes. Apparently, the terminal repeat is regenerated from the internal repeat.

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References

    1. Virology. 1979 Aug;97(1):151-63 - PubMed
    1. Vet Q. 1982 Apr;4(2):49-56 - PubMed
    1. Arch Virol. 1980;63(2):107-14 - PubMed
    1. Virology. 1984 Jan 30;132(2):303-14 - PubMed
    1. Virology. 1983 May;127(1):194-204 - PubMed

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