doi: 10.1128/JVI.53.3.984-987.1985.
Nucleotide sequence analysis of the BALB/c murine sarcoma virus transforming gene
- PMID: 2983103
- PMCID: PMC254738
- DOI: 10.1128/JVI.53.3.984-987.1985
Item in Clipboard
Nucleotide sequence analysis of the BALB/c murine sarcoma virus transforming gene
J Virol.
1985 Mar.
Abstract
We determined the nucleotide sequence of the v-H-ras-related oncogene of BALB/c murine sarcoma virus. This oncogene contains an open reading frame of 189 amino acids that initiates and terminates entirely within the mouse cell-derived ras sequence. The protein encoded by this open reading frame matches the sequence predicted for the T24 human bladder carcinoma oncogene product, p21, in all but two positions. The presence of a lysine residue in position 12 of BALB/c murine sarcoma virus p21 likely accounts for its oncogenic properties.
Similar articles
-
Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus.Science. 1982 Sep 3;217(4563):937-9. doi: 10.1126/science.6287573. Science. 1982. PMID: 6287573
-
Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins.Proc Natl Acad Sci U S A. 1984 Sep;81(17):5305-9. doi: 10.1073/pnas.81.17.5305. Proc Natl Acad Sci U S A. 1984. PMID: 6089191 Free PMC article.
-
Analysis of viral and somatic activations of the cHa-ras gene.J Virol. 1985 Jan;53(1):260-5. doi: 10.1128/JVI.53.1.260-265.1985. J Virol. 1985. PMID: 2981345 Free PMC article.
-
Nucleotide sequence of avian carcinoma virus MH2: two potential onc genes, one related to avian virus MC29 and the other related to murine sarcoma virus 3611.Proc Natl Acad Sci U S A. 1984 May;81(10):3000-4. doi: 10.1073/pnas.81.10.3000. Proc Natl Acad Sci U S A. 1984. PMID: 6328485 Free PMC article.
-
Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells.J Mol Appl Genet. 1983;2(2):173-80. J Mol Appl Genet. 1983. PMID: 6308118
Cited by
-
The malignant histiocytosis sarcoma virus, a recombinant of Harvey murine sarcoma virus and Friend mink cell focus-forming virus, has acquired myeloid transformation specificity by alterations in the long terminal repeat.J Virol. 1990 Jan;64(1):369-78. doi: 10.1128/JVI.64.1.369-378.1990. J Virol. 1990. PMID: 2152823 Free PMC article.
-
Kirsten Ras* oncogene: significance of its discovery in human cancer research.Oncotarget. 2016 Jul 19;7(29):46717-46733. doi: 10.18632/oncotarget.8773. Oncotarget. 2016. PMID: 27102293 Free PMC article. Review.
-
Harvey ras genes transform without mutant codons, apparently activated by truncation of a 5' exon (exon -1).Proc Natl Acad Sci U S A. 1986 Apr;83(8):2340-4. doi: 10.1073/pnas.83.8.2340. Proc Natl Acad Sci U S A. 1986. PMID: 3517865 Free PMC article.
-
Anoxia-inducible rat VL30 elements and their relationship to ras-containing sarcoma viruses.J Virol. 1993 Nov;67(11):6857-62. doi: 10.1128/JVI.67.11.6857-6862.1993. J Virol. 1993. PMID: 8411389 Free PMC article.
-
Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.J Virol. 1989 Jul;63(7):2959-66. doi: 10.1128/JVI.63.7.2959-2966.1989. J Virol. 1989. PMID: 2542606 Free PMC article.
References
MeSH terms
Associated data
- Actions
LinkOut - more resources
Full Text Sources
