Translocation of oncogene c-sis from chromosome 22 to chromosome 11 in a Ewing sarcoma-derived cell line
- PMID: 2983195
- PMCID: PMC366729
- DOI: 10.1128/mcb.5.2.427-429.1985
Translocation of oncogene c-sis from chromosome 22 to chromosome 11 in a Ewing sarcoma-derived cell line
Abstract
Somatic cell hybrids, obtained after fusion of translocation (11;22)-positive Ewing sarcoma cells and Chinese hamster fibroblasts, were assayed for the presence of immunoglobulin C lambda, Philadelphia chromosome breakpoint cluster region, and c-sis oncogene sequences. It was found that c-sis was translocated from chromosome 22 to chromosome 11 in the Ewing sarcoma cells used, indicating that the breakpoint must be proximal to this locus. Moreover, we found that the chromosome 22-linked C lambda and breakpoint cluster region sequences are not translocated. This result confirms an earlier cytogenetic observation that the Ewing sarcoma-associated breakpoint in chromosome 22 is distal to those observed in translocation (8;22)-positive Burkitt lymphoma and in Philadelphia chromosome-positive chronic myeloid leukemia.
Similar articles
-
c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia.J Exp Med. 1983 Jul 1;158(1):9-15. doi: 10.1084/jem.158.1.9. J Exp Med. 1983. PMID: 6306134 Free PMC article.
-
Isolation and analysis of the 21q+ chromosome in the acute myelogenous leukemia 8;21 translocation: evidence that c-mos is not translocated.Proc Natl Acad Sci U S A. 1985 Jan;82(2):464-8. doi: 10.1073/pnas.82.2.464. Proc Natl Acad Sci U S A. 1985. PMID: 2982159 Free PMC article.
-
Mapping of the c-sis oncogene on human chromosome 22 with respect to the breakpoint associated with chronic myeloid leukaemia.Biosci Rep. 1983 Dec;3(12):1107-11. doi: 10.1007/BF01120203. Biosci Rep. 1983. PMID: 6582938
-
[Identification of the breakpoint-flanking markers on chromosomes 1 and 17 of a constitutional translocation T(1;17)(P36;Q12-21) in a patient with neuroblastoma].Verh K Acad Geneeskd Belg. 1995;57(5):389-422. Verh K Acad Geneeskd Belg. 1995. PMID: 8571670 Review. Dutch.
-
Chromosomal in situ hybridization and the molecular cytogenetics of cancer.Surv Synth Pathol Res. 1985;4(4):269-81. doi: 10.1159/000156980. Surv Synth Pathol Res. 1985. PMID: 3915389 Review. No abstract available.
Cited by
-
A new polymorphic probe on chromosome 22: NB17 (D22S181).Nucleic Acids Res. 1991 Feb 11;19(3):686. Nucleic Acids Res. 1991. PMID: 1672761 Free PMC article. No abstract available.
-
Human chromosome 22.J Med Genet. 1987 Feb;24(2):65-78. doi: 10.1136/jmg.24.2.65. J Med Genet. 1987. PMID: 3550088 Free PMC article. Review.
-
A new polymorphic probe on chromosome 22q: NB129 (D22S193).Nucleic Acids Res. 1991 Feb 11;19(3):687. Nucleic Acids Res. 1991. PMID: 1672764 Free PMC article. No abstract available.
-
Isolation and mapping of cosmid markers on human chromosome 22, including one within the submicroscopically deleted region of DiGeorge syndrome.Hum Genet. 1994 Mar;93(3):248-54. doi: 10.1007/BF00212017. Hum Genet. 1994. PMID: 7907312
-
Role of human chromosome 11 in determining surface antigenic phenotype of normal and malignant cells. Somatic cell genetic analysis of eight antigens, including putative human Thy-1.J Exp Med. 1985 Nov 1;162(5):1603-19. doi: 10.1084/jem.162.5.1603. J Exp Med. 1985. PMID: 2865325 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
