Comparative Study
doi: 10.1038/313756a0.
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
- PMID: 2983222
- DOI: 10.1038/313756a0
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Comparative Study
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
Nature.
1985.
Abstract
We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor alpha-subunit, a precursor processing enzyme cleavage site, then the beta-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
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